biostudies-literatureSkoog PRegion Örebro länUniversity of GothenburgUniversitetssjukhuset Örebro42-50https://www.ebi.ac.uk/biostudies/studies/S-EPMC9944725biostudies-literatureUnknown16(1)Intraabdominal hypertension (IAH) is negative for outcome after intensive care. Little research has focused on medical intervention to improve visceral circulation during IAH. A nitric oxide (NO)-donor was compared with placebo in 25 pigs; each pig was randomized into three groups: PDNO (NO-donor), Control (placebo), or Sham. IAH was induced by CO₂ insufflation to 30 mmHg. Sham group had surgical preparation only. Blood gases, invasive venous and arterial blood pressure, intestinal microcirculation and superior mesenteric blood flow were measured. The PDNO group had significantly increased intestinal microcirculation compared with Controls during IAH (last hour, P = 0.009). The mean arterial pressure and abdominal perfusion pressures (APP) were decreased, and the cardiac index wJournal of cardiovascular translational researchNO-Donation Increases Visceral Circulation in a Porcine Model of Abdominal Hypertension.PMC9944725OLL-506681OLL-929955Nilsson KFSkoog PHorer TMSeilitz JOikonomakis IfalseNO-Donation Increases Visceral Circulation in a Porcine Model of Abdominal Hypertension.Intraabdominal hypertension (IAH) is negative for outcome after intensive care. Little research has focused on medical intervention to improve visceral circulation during IAH. A nitric oxide (NO)-donor was compared with placebo in 25 pigs; each pig was randomized into three groups: PDNO (NO-donor), Control (placebo), or Sham. IAH was induced by CO₂ insufflation to 30 mmHg. Sham group had surgical preparation only. Blood gases, invasive venous and arterial blood pressure, intestinal microcirculation and superior mesenteric blood flow were measured. The PDNO group had significantly increased intestinal microcirculation compared with Controls during IAH (last hour, P = 0.009). The mean arterial pressure and abdominal perfusion pressures (APP) were decreased, and the cardiac index w2023-01-01T00:00:00Z2023 Feb2025-06-01T01:39:49.539Z2024-11-14T06:24:17.193ZS-EPMC99447253603686010.1007/s12265-022-10299-w