biostudies-literatureRao SBritish Heart FoundationNational Institute for Health Research (NIHR)598-607https://www.ebi.ac.uk/biostudies/studies/S-EPMC9944753biostudies-literatureUnknown80(3)<h4>Background</h4>Whether the association between systolic blood pressure (SBP) and risk of cardiovascular disease is monotonic or whether there is a nadir of optimal blood pressure remains controversial. We investigated the association between SBP and cardiovascular events in patients with diabetes across the full spectrum of SBP.<h4>Methods</h4>A cohort of 49 000 individuals with diabetes aged 50 to 90 years between 1990 and 2005 was identified from linked electronic health records in the United Kingdom. Associations between SBP and cardiovascular outcomes (ischemic heart disease, heart failure, stroke, and cardiovascular death) were analyzed using a deep learning approach.<h4>Results</h4>Over a median follow-up of 7.3 years, 16 378 cardiovascular events were observed. The relationship Hypertension (Dallas, Tex. : 1979)Systolic Blood Pressure and Cardiovascular Risk in Patients With Diabetes: A Prospective Cohort Study.PMC9944753FS/IPBSRF/22/27060FS/PHD/21/29110FS/19/36/34346PG/18/65/33872Salimi-Khorshidi GRao SLi YHassaine ACanoy DMamouei MRahimi KNazarzadeh MfalseSystolic Blood Pressure and Cardiovascular Risk in Patients With Diabetes: A Prospective Cohort Study.<h4>Background</h4>Whether the association between systolic blood pressure (SBP) and risk of cardiovascular disease is monotonic or whether there is a nadir of optimal blood pressure remains controversial. We investigated the association between SBP and cardiovascular events in patients with diabetes across the full spectrum of SBP.<h4>Methods</h4>A cohort of 49 000 individuals with diabetes aged 50 to 90 years between 1990 and 2005 was identified from linked electronic health records in the United Kingdom. Associations between SBP and cardiovascular outcomes (ischemic heart disease, heart failure, stroke, and cardiovascular death) were analyzed using a deep learning approach.<h4>Results</h4>Over a median follow-up of 7.3 years, 16 378 cardiovascular events were observed. The relationship 2023-01-01T00:00:00Z2023 Mar2026-06-13T06:11:55.01Z2025-02-19T02:23:56.051ZS-EPMC99447533658338610.1161/HYPERTENSIONAHA.122.20489