{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(7)"],"submitter":["Valentini F"],"pubmed_abstract":["We herein report a waste minimization protocol for the β-azidation of α,β-unsaturated carbonyl compounds using TMSN<sub>3</sub>. The selection of the appropriate catalyst (<b>POLITAG-M-F</b>), in combination with the reaction medium, resulted in enhanced catalytic efficiency and a low environmental footprint. The thermal and mechanical stability of the polymeric support allowed us to recover the <b>POLITAG-M-F</b> catalyst for up to 10 consecutive runs. The CH<sub>3</sub>CN:H<sub>2</sub>O azeotrope has a 2-fold positive effect on the process, increasing the efficiency of the protocol and minimizing waste generation. Indeed, the azeotropic mixture, used as a reaction medium and for the workup procedure, was recovered by distillation, leading to an easy and environmentally friendly procedure for product isolation in high yield and with a low E-factor. A comprehensive evaluation of the environmental profile was performed by the calculation of different green metrics (AE, RME, MRP, 1/SF) and a comparison with other literature available protocols. A flow protocol was defined to scale-up the process, and up to 65 mmol of substrates were efficiently converted with a productivity of 0.3 mmol/min."],"journal":["ACS sustainable chemistry & engineering"],"pagination":["3074-3084"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9945162"],"repository":["biostudies-literature"],"pubmed_title":["POLITAG-M-F as Heterogeneous Organocatalyst for the Waste-Minimized Synthesis of β-Azido Carbonyl Compounds in Batch and under Flow Conditions."],"pmcid":["PMC9945162"],"pubmed_authors":["Campana F","Lanari D","Valentini F","Vaccaro L","Rossini G","Brufani G"],"additional_accession":[]},"is_claimable":false,"name":"POLITAG-M-F as Heterogeneous Organocatalyst for the Waste-Minimized Synthesis of β-Azido Carbonyl Compounds in Batch and under Flow Conditions.","description":"We herein report a waste minimization protocol for the β-azidation of α,β-unsaturated carbonyl compounds using TMSN<sub>3</sub>. The selection of the appropriate catalyst (<b>POLITAG-M-F</b>), in combination with the reaction medium, resulted in enhanced catalytic efficiency and a low environmental footprint. The thermal and mechanical stability of the polymeric support allowed us to recover the <b>POLITAG-M-F</b> catalyst for up to 10 consecutive runs. The CH<sub>3</sub>CN:H<sub>2</sub>O azeotrope has a 2-fold positive effect on the process, increasing the efficiency of the protocol and minimizing waste generation. Indeed, the azeotropic mixture, used as a reaction medium and for the workup procedure, was recovered by distillation, leading to an easy and environmentally friendly procedure for product isolation in high yield and with a low E-factor. A comprehensive evaluation of the environmental profile was performed by the calculation of different green metrics (AE, RME, MRP, 1/SF) and a comparison with other literature available protocols. A flow protocol was defined to scale-up the process, and up to 65 mmol of substrates were efficiently converted with a productivity of 0.3 mmol/min.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2024-11-21T07:30:33.887Z","creation":"2024-11-21T07:30:33.887Z"},"accession":"S-EPMC9945162","cross_references":{"pubmed":["36844749"],"doi":["10.1021/acssuschemeng.2c07213"]}}