{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["131(2)"],"submitter":["Okamura T"],"pubmed_abstract":["<h4>Background</h4>Microplastics (MPs) are small particles of plastic (≤5mm in diameter). In recent years, oral exposure to MPs in living organisms has been a cause of concern. Leaky gut syndrome (LGS), associated with a high-fat diet (HFD) in mice, can increase the entry of foreign substances into the body through the intestinal mucosa.<h4>Objectives</h4>We aimed to evaluate the pathophysiology of intestinal outcomes associated with consuming a high-fat diet and simultaneous intake of MPs, focusing on endocrine and metabolic systems.<h4>Methods</h4>C57BL6/J mice were fed a normal diet (ND) or HFD with or without polystyrene MP for 4 wk to investigate differences in glucose tolerance, intestinal permeability, gut microbiota, as well as metabolites in serum, feces, and liver.<h4>Results</h4"],"journal":["Environmental health perspectives"],"pagination":["27006"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9945580"],"repository":["biostudies-literature"],"pubmed_title":["Oral Exposure to Polystyrene Microplastics of Mice on a Normal or High-Fat Diet and Intestinal and Metabolic Outcomes."],"pmcid":["PMC9945580"],"pubmed_authors":["Asano M","Yamazaki M","Senmaru T","Nakanishi Y","Fukui M","Majima S","Sasano R","Hasegawa Y","Takano H","Okamura T","Hashimoto Y","Nakanishi N","Hamaguchi M","Seno H","Ushigome E"],"additional_accession":[]},"is_claimable":false,"name":"Oral Exposure to Polystyrene Microplastics of Mice on a Normal or High-Fat Diet and Intestinal and Metabolic Outcomes.","description":"<h4>Background</h4>Microplastics (MPs) are small particles of plastic (≤5mm in diameter). In recent years, oral exposure to MPs in living organisms has been a cause of concern. Leaky gut syndrome (LGS), associated with a high-fat diet (HFD) in mice, can increase the entry of foreign substances into the body through the intestinal mucosa.<h4>Objectives</h4>We aimed to evaluate the pathophysiology of intestinal outcomes associated with consuming a high-fat diet and simultaneous intake of MPs, focusing on endocrine and metabolic systems.<h4>Methods</h4>C57BL6/J mice were fed a normal diet (ND) or HFD with or without polystyrene MP for 4 wk to investigate differences in glucose tolerance, intestinal permeability, gut microbiota, as well as metabolites in serum, feces, and liver.<h4>Results</h4","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-07-14T22:23:57.193Z","creation":"2025-04-06T11:43:59.912Z"},"accession":"S-EPMC9945580","cross_references":{"pubmed":["36821708"],"doi":["10.1289/EHP11072"]}}