{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goncalves BMF"],"funding":["Universidade de Coimbra","Programa Operacional Regional do Centro","European Regional Development Fund"],"pagination":["313-331"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9945870"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["Arjunolic acid (AA) is a pentacyclic triterpenoid with promising anticancer properties. A series of novel AA derivatives containing a pentameric A-ring with an enal moiety, combined with additional modifications at C-28, were designed and prepared. The biological activity on the viability of human cancer and non-tumor cell lines was evaluated in order to identify the most promising derivatives. Additionally, a preliminary study of the structure-activity relationship was carried out. The most active derivative, derivative 26, also showed the best selectivity between malignant cells and non-malignant fibroblasts. For compound 26, the anticancer molecular mechanism of action in PANC-1 cells was further studied and the results showed that this derivative induced a cell-cycle arrest at G0/G1 ph"],"journal":["RSC medicinal chemistry"],"pubmed_title":["Design, synthesis, and biological evaluation of new arjunolic acid derivatives as anticancer agents."],"pmcid":["PMC9945870"],"funding_grant_id":["CENTRO-01-0247-FEDER-003269"],"pubmed_authors":["Salvador JAR","Goncalves BMF","Silvestre SM","Mendes VIS"],"additional_accession":[]},"is_claimable":false,"name":"Design, synthesis, and biological evaluation of new arjunolic acid derivatives as anticancer agents.","description":"Arjunolic acid (AA) is a pentacyclic triterpenoid with promising anticancer properties. A series of novel AA derivatives containing a pentameric A-ring with an enal moiety, combined with additional modifications at C-28, were designed and prepared. The biological activity on the viability of human cancer and non-tumor cell lines was evaluated in order to identify the most promising derivatives. Additionally, a preliminary study of the structure-activity relationship was carried out. The most active derivative, derivative 26, also showed the best selectivity between malignant cells and non-malignant fibroblasts. For compound 26, the anticancer molecular mechanism of action in PANC-1 cells was further studied and the results showed that this derivative induced a cell-cycle arrest at G0/G1 ph","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-03-18T14:08:16.32Z","creation":"2025-08-23T03:09:06.433Z"},"accession":"S-EPMC9945870","cross_references":{"pubmed":["36846362"],"doi":["10.1039/d2md00275b"]}}