biostudies-literatureUnknown64(2)Loewinger AS<h4>Purpose</h4>To quantify choriocapillaris flow alterations in patients with pseudoxanthoma elasticum (PXE) in pre-atrophic stages and its association with structural changes of the choroid and outer retina.<h4>Methods</h4>Thirty-two eyes of 21 patients with PXE and 35 healthy eyes of 35 controls were included. The density of choriocapillaris flow signal deficits (FDs) was quantified on 6 × 6-mm optical coherence tomography angiography (OCTA) images. Spectral-domain optical coherence tomography (SD-OCT) images were analyzed for thicknesses of the choroid and outer retinal microstructure and correlated with choriocapillaris FDs in the respective Early Treatment Diabetic Retinopathy Study subfield.<h4>Results</h4>The multivariable mixed model analysis for choriocapillaris FDs revealed signInvestigative ophthalmology & visual science21https://www.ebi.ac.uk/biostudies/studies/S-EPMC9946047biostudies-literatureChoriocapillaris Flow Signal Impairment in Patients With Pseudoxanthoma Elasticum.PMC9946047Loewinger ASHolz FGPfau MPfau KHerrmann PfalseChoriocapillaris Flow Signal Impairment in Patients With Pseudoxanthoma Elasticum.<h4>Purpose</h4>To quantify choriocapillaris flow alterations in patients with pseudoxanthoma elasticum (PXE) in pre-atrophic stages and its association with structural changes of the choroid and outer retina.<h4>Methods</h4>Thirty-two eyes of 21 patients with PXE and 35 healthy eyes of 35 controls were included. The density of choriocapillaris flow signal deficits (FDs) was quantified on 6 × 6-mm optical coherence tomography angiography (OCTA) images. Spectral-domain optical coherence tomography (SD-OCT) images were analyzed for thicknesses of the choroid and outer retinal microstructure and correlated with choriocapillaris FDs in the respective Early Treatment Diabetic Retinopathy Study subfield.<h4>Results</h4>The multivariable mixed model analysis for choriocapillaris FDs revealed sign2023-01-01T00:00:00Z2023 Feb2026-05-28T17:46:47.316Z2025-04-04T11:27:08.783ZS-EPMC99460473680930210.1167/iovs.64.2.21