biostudies-literatureBallouz TDepartment of Health, Canton of Zurich, SwitzerlandUniversity of Zurich (UZH) FoundationSwiss School of Public HealthUniversity of Zurich (UZH) Postdoc GrantH2020 Marie Skłodowska-Curie ActionsSwiss Federal Office of Public Healthe0281429https://www.ebi.ac.uk/biostudies/studies/S-EPMC9946205biostudies-literatureUnknown18(2)<h4>Background</h4>Post COVID-19 condition (PCC) is an important complication of SARS-CoV-2 infection, affecting millions worldwide. This study aimed to evaluate the prevalence and severity of post COVID-19 condition (PCC) with novel SARS-CoV-2 variants and after prior vaccination.<h4>Methods</h4>We used pooled data from 1350 SARS-CoV-2-infected individuals from two representative population-based cohorts in Switzerland, diagnosed between Aug 5, 2020, and Feb 25, 2022. We descriptively analysed the prevalence and severity of PCC, defined as the presence and frequency of PCC-related symptoms six months after infection, among vaccinated and non-vaccinated individuals infected with Wildtype, Delta, and Omicron SARS-CoV-2. We used multivariable logistic regression models to assess the associatPloS onePost COVID-19 condition after Wildtype, Delta, and Omicron SARS-CoV-2 infection and prior vaccination: Pooled analysis of two population-based cohorts.PMC9946205FK-22-053801076Menges DAlbanese EFrei AKaufmann MFehr JSPuhan MAvon Wyl VAmati RBallouz TfalsePost COVID-19 condition after Wildtype, Delta, and Omicron SARS-CoV-2 infection and prior vaccination: Pooled analysis of two population-based cohorts.<h4>Background</h4>Post COVID-19 condition (PCC) is an important complication of SARS-CoV-2 infection, affecting millions worldwide. This study aimed to evaluate the prevalence and severity of post COVID-19 condition (PCC) with novel SARS-CoV-2 variants and after prior vaccination.<h4>Methods</h4>We used pooled data from 1350 SARS-CoV-2-infected individuals from two representative population-based cohorts in Switzerland, diagnosed between Aug 5, 2020, and Feb 25, 2022. We descriptively analysed the prevalence and severity of PCC, defined as the presence and frequency of PCC-related symptoms six months after infection, among vaccinated and non-vaccinated individuals infected with Wildtype, Delta, and Omicron SARS-CoV-2. We used multivariable logistic regression models to assess the associat2023-01-01T00:00:00Z20232025-04-04T22:38:48.807Z2025-04-04T22:38:48.807ZS-EPMC99462053681221510.1371/journal.pone.0281429