biostudies-literatureUnknown13(1)Franco JJMukai Fund, Massachusetts Eye and Ear, Boston, USAReliable centrifugation for medical applications has historically required access to expensive, bulky, and electricity-dependent commercial devices, which are generally unavailable in resource-poor settings. Although several portable, low-cost, non-electric centrifuges have been described, these solutions have predominately been designed for diagnostic applications requiring sedimentation of relatively small volumes. Moreover, construction of these devices frequently requires access to specialized materials and tools that are often unavailable in underserved areas. Herein, we describe the design, assembly, and experimental validation of the CentREUSE-an ultralow-cost, portable, discarded material-based, human-powered centrifuge for use in therapeutic applications. The CentREUSE demonstrateScientific reports3081https://www.ebi.ac.uk/biostudies/studies/S-EPMC9946952biostudies-literatureAn ultralow-cost portable centrifuge from discarded materials for medical applications.PMC9946952Nagata TMukai SFranco JJOkamoto TfalseAn ultralow-cost portable centrifuge from discarded materials for medical applications.Reliable centrifugation for medical applications has historically required access to expensive, bulky, and electricity-dependent commercial devices, which are generally unavailable in resource-poor settings. Although several portable, low-cost, non-electric centrifuges have been described, these solutions have predominately been designed for diagnostic applications requiring sedimentation of relatively small volumes. Moreover, construction of these devices frequently requires access to specialized materials and tools that are often unavailable in underserved areas. Herein, we describe the design, assembly, and experimental validation of the CentREUSE-an ultralow-cost, portable, discarded material-based, human-powered centrifuge for use in therapeutic applications. The CentREUSE demonstrate2023-01-01T00:00:00Z2023 Feb2026-06-03T18:26:28.182Z2025-04-05T11:14:13.604ZS-EPMC99469523681383510.1038/s41598-023-30327-2