{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de la Torre-Martinez R"],"funding":["Vetenskapsrådet","Hjärnfonden (Swedish Brain Foundation)","Vetenskapsrådet (Swedish Research Council)","Hjärnfonden","Knut och Alice Wallenbergs Stiftelse","Knut och Alice Wallenbergs Stiftelse (Knut and Alice Wallenberg Foundation)"],"pagination":["1004"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9947004"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["The dorsolateral striatum (DLS) receives excitatory inputs from both sensory and motor cortical regions. In the neocortex, sensory responses are affected by motor activity, however, it is not known whether such sensorimotor interactions occur in the striatum and how they are shaped by dopamine. To determine the impact of motor activity on striatal sensory processing, we performed in vivo whole-cell recordings in the DLS of awake mice during the presentation of tactile stimuli. Striatal medium spiny neurons (MSNs) were activated by both whisker stimulation and spontaneous whisking, however, their responses to whisker deflection during ongoing whisking were attenuated. Dopamine depletion reduced the representation of whisking in direct-pathway MSNs, but not in those of the indirect-pathway. "],"journal":["Nature communications"],"pubmed_title":["Ongoing movement controls sensory integration in the dorsolateral striatum."],"pmcid":["PMC9947004"],"funding_grant_id":["2019-0 1254","FO2021-0333","KAW 2017.0273"],"pubmed_authors":["de la Torre-Martinez R","Ketzef M","Silberberg G"],"additional_accession":[]},"is_claimable":false,"name":"Ongoing movement controls sensory integration in the dorsolateral striatum.","description":"The dorsolateral striatum (DLS) receives excitatory inputs from both sensory and motor cortical regions. In the neocortex, sensory responses are affected by motor activity, however, it is not known whether such sensorimotor interactions occur in the striatum and how they are shaped by dopamine. To determine the impact of motor activity on striatal sensory processing, we performed in vivo whole-cell recordings in the DLS of awake mice during the presentation of tactile stimuli. Striatal medium spiny neurons (MSNs) were activated by both whisker stimulation and spontaneous whisking, however, their responses to whisker deflection during ongoing whisking were attenuated. Dopamine depletion reduced the representation of whisking in direct-pathway MSNs, but not in those of the indirect-pathway. ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-29T21:11:56.062Z","creation":"2025-05-29T21:11:56.062Z"},"accession":"S-EPMC9947004","cross_references":{"pubmed":["36813791"],"doi":["10.1038/s41467-023-36648-0"]}}