biostudies-literatureUnknown31(3)El-Shiekh RACairo UniversityAcute lung injury (ALI) is a life-threatening condition usually associated with poor therapeutic outcomes and a high mortality rate. Since 2019, the situation has worsened due to the COVID-19 pandemic. ALI had approximately 40% of deaths before COVID-19, mainly due to the dysfunction of the blood-gas barrier that led to lung edema, failure of gas exchange, and dyspnea. Many strategies have been taken to mitigate the disease condition, such as diuretics, surfactants, antioxidants, glucocorticoids, heparin, and ventilators with concomitant sedatives. However, until now, there is no available effective therapy for ALI. Thus, we are presenting a new compound termed Arabincoside B (AR-B), recently isolated from Caralluma arabica, to be tested in such conditions. For that, the lipopolysaccharideInflammopharmacology1437-1447https://www.ebi.ac.uk/biostudies/studies/S-EPMC9948789biostudies-literatureArabincoside B isolated from Caralluma arabica as a potential anti-pneumonitis in LPS mice model.PMC9948789El-Shiekh RAAl-Hawshabi OSSShokry AANabil GAhmed YHAbdel-Sattar EfalseArabincoside B isolated from Caralluma arabica as a potential anti-pneumonitis in LPS mice model.Acute lung injury (ALI) is a life-threatening condition usually associated with poor therapeutic outcomes and a high mortality rate. Since 2019, the situation has worsened due to the COVID-19 pandemic. ALI had approximately 40% of deaths before COVID-19, mainly due to the dysfunction of the blood-gas barrier that led to lung edema, failure of gas exchange, and dyspnea. Many strategies have been taken to mitigate the disease condition, such as diuretics, surfactants, antioxidants, glucocorticoids, heparin, and ventilators with concomitant sedatives. However, until now, there is no available effective therapy for ALI. Thus, we are presenting a new compound termed Arabincoside B (AR-B), recently isolated from Caralluma arabica, to be tested in such conditions. For that, the lipopolysaccharide2023-01-01T00:00:00Z2023 Jun2026-06-11T05:48:47.067Z2024-11-13T04:04:21.542ZS-EPMC99487893682094310.1007/s10787-023-01159-3