{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Geben LC"],"funding":["NEI NIH HHS","NICHD NIH HHS","NIDDK NIH HHS","NINDS NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pubmed_abstract":["A limiting factor in the regenerative capacity of the adult brain is the abundance and proliferative ability of neural stem cells (NSCs). Adult NSCs are derived from a subpopulation of embryonic NSCs that temporarily enter quiescence during mid-gestation and remain quiescent until postnatal reactivation. Here we present evidence that the mechanistic/mammalian target of rapamycin (mTOR) pathway regulates quiescence entry in embryonic NSCs of the developing forebrain. Throughout embryogenesis, two downstream effectors of mTOR, p-4EBP1/2 T37/46 and p-S6 S240/244, were mutually exclusive in NSCs, rarely occurring in the same cell. While 4EBP1/2 was phosphorylated in stem cells undergoing mitosis at the ventricular surface, S6 was phosphorylated in more differentiated cells migrating away from "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2023.02.14.528513"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9948964"],"repository":["biostudies-literature"],"pubmed_title":["Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence."],"pmcid":["PMC9948964"],"funding_grant_id":["T32 GM007628","F31 NS120608","F31 HD106890","U24 DK059637","P30 DK058404","T32 HD007502","P30 EY008126","U54 CA217450","P30 DK020593","R01 DK106476","P30 CA068485","R01 NS118580","R01 NS096238","R01 CA226833"],"pubmed_authors":["Gallagher JE","Brockman AA","Scheuing AL","Irish JM","Ess KC","Chalkley MBL","Simerly RB","Sweet SR","Ihrie RA","Geben LC"],"additional_accession":[]},"is_claimable":false,"name":"Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence.","description":"A limiting factor in the regenerative capacity of the adult brain is the abundance and proliferative ability of neural stem cells (NSCs). Adult NSCs are derived from a subpopulation of embryonic NSCs that temporarily enter quiescence during mid-gestation and remain quiescent until postnatal reactivation. Here we present evidence that the mechanistic/mammalian target of rapamycin (mTOR) pathway regulates quiescence entry in embryonic NSCs of the developing forebrain. Throughout embryogenesis, two downstream effectors of mTOR, p-4EBP1/2 T37/46 and p-S6 S240/244, were mutually exclusive in NSCs, rarely occurring in the same cell. While 4EBP1/2 was phosphorylated in stem cells undergoing mitosis at the ventricular surface, S6 was phosphorylated in more differentiated cells migrating away from ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-19T13:32:55.602Z","creation":"2025-04-19T13:32:55.602Z"},"accession":"S-EPMC9948964","cross_references":{"pubmed":["36824760"],"doi":["10.1101/2023.02.14.528513"]}}