{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2023"],"submitter":["Yang M"],"pubmed_abstract":["<h4>Background</h4>Non-small cell lung cancer (NSCLC) is a crucial crux of cancer-related death, and M2 macrophage polarization facilitates NSCLC development. MicroRNA-613 (miR-613) is a tumor suppressor. This research aimed to clarify the miR-613 function in NSCLC and its impact on M2 macrophage polarization. <i>Methods.</i> miR-613 expressions in NSCLC tissues and cells were evaluated using quantitative real-time PCR. For miR-613 function in NSCLC, cell proliferation analysis, cell counting kit-8, flow cytometry, western blot, transwell, and wound-healing were conducted. Meanwhile, the miR-613 impact on M2 macrophage polarization was assessed by the NSCLC models. <i>Results.</i> miR-613 was lessened in NSCLC cells and tissues. It was corroborated that miR-613 overexpression retrained NSCLC cell proliferation, invasion, and migration but facilitated cell apoptosis. Moreover, miR-613 overexpression restrained NSCLC development by repressing M2 macrophage polarization.<h4>Conclusion</h4>Tumor suppressor miR-613 ameliorated NSCLC by restraining M2 macrophage polarization."],"journal":["Journal of oncology"],"pagination":["2311231"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9950322"],"repository":["biostudies-literature"],"pubmed_title":["Tumor Suppressor miR-613 Alleviates Non-Small Cell Lung Cancer Cell via Repressing M2 Macrophage Polarization."],"pmcid":["PMC9950322"],"pubmed_authors":["Xu M","Shi M","Yang M","Han X","Zhou W","Wang Z","Shi Y"],"additional_accession":[]},"is_claimable":false,"name":"Tumor Suppressor miR-613 Alleviates Non-Small Cell Lung Cancer Cell via Repressing M2 Macrophage Polarization.","description":"<h4>Background</h4>Non-small cell lung cancer (NSCLC) is a crucial crux of cancer-related death, and M2 macrophage polarization facilitates NSCLC development. MicroRNA-613 (miR-613) is a tumor suppressor. This research aimed to clarify the miR-613 function in NSCLC and its impact on M2 macrophage polarization. <i>Methods.</i> miR-613 expressions in NSCLC tissues and cells were evaluated using quantitative real-time PCR. For miR-613 function in NSCLC, cell proliferation analysis, cell counting kit-8, flow cytometry, western blot, transwell, and wound-healing were conducted. Meanwhile, the miR-613 impact on M2 macrophage polarization was assessed by the NSCLC models. <i>Results.</i> miR-613 was lessened in NSCLC cells and tissues. It was corroborated that miR-613 overexpression retrained NSCLC cell proliferation, invasion, and migration but facilitated cell apoptosis. Moreover, miR-613 overexpression restrained NSCLC development by repressing M2 macrophage polarization.<h4>Conclusion</h4>Tumor suppressor miR-613 ameliorated NSCLC by restraining M2 macrophage polarization.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-05T13:21:20.062Z","creation":"2025-04-05T13:21:20.062Z"},"accession":"S-EPMC9950322","cross_references":{"pubmed":["36844868"],"doi":["10.1155/2023/2311231"]}}