{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Takahara K"],"pubmed_abstract":["<h4>Objective</h4>The goal of schwannoma resection is to control the tumor while preserving neurological function. Schwannomas have a variable postoperative growth pattern, therefore preoperative prediction of a schwannoma's growth pattern is favorable. This study aimed to examine the relationship between preoperative neutrophil-to-lymphocyte ratio (NLR) and postoperative recurrence and retreatment in patients with schwannoma.<h4>Methods</h4>We retrospectively examined 124 patients who underwent schwannoma resection in our institution. Associations between preoperative NLR, other patient and tumor characteristics, and tumor recurrence and retreatment were analyzed.<h4>Results</h4>Median follow-up was 2569.5 days. Postoperative recurrence occurred in 37 patients. Recurrence that required retreatment occurred in 22. Treatment-free survival (TFS) was significantly shorter in patients with NLR ≥2.21 (<i>P</i> = 0.0010). Multivariate Cox proportional hazards regression showed that NLR and neurofibromatosis type 2 were independent predictors of retreatment (<i>P</i> = 0.0423 and 0.0043, respectively). TFS was significantly shorter in patients with NLR ≥2.21 in the following subgroups: sporadic schwannoma, primary schwannoma, schwannoma ≥30 mm in size, subtotal resection, vestibular schwannoma, and postoperative recurrence.<h4>Conclusions</h4>Preoperative NLR ≥2.21 before surgery was significantly associated with retreatment after schwannoma resection. NLR may be a novel predictor of retreatment and assist surgeons in preoperative surgical decision making."],"journal":["Frontiers in oncology"],"pagination":["1099384"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9950385"],"repository":["biostudies-literature"],"pubmed_title":["Prognostic significance of preoperative neutrophil-to-lymphocyte ratio in surgically resected schwannomas."],"pmcid":["PMC9950385"],"pubmed_authors":["Kuranari Y","Takahara K","Tamura R","Toda M","Karatsu K","Akiyama T"],"additional_accession":[]},"is_claimable":false,"name":"Prognostic significance of preoperative neutrophil-to-lymphocyte ratio in surgically resected schwannomas.","description":"<h4>Objective</h4>The goal of schwannoma resection is to control the tumor while preserving neurological function. Schwannomas have a variable postoperative growth pattern, therefore preoperative prediction of a schwannoma's growth pattern is favorable. This study aimed to examine the relationship between preoperative neutrophil-to-lymphocyte ratio (NLR) and postoperative recurrence and retreatment in patients with schwannoma.<h4>Methods</h4>We retrospectively examined 124 patients who underwent schwannoma resection in our institution. Associations between preoperative NLR, other patient and tumor characteristics, and tumor recurrence and retreatment were analyzed.<h4>Results</h4>Median follow-up was 2569.5 days. Postoperative recurrence occurred in 37 patients. Recurrence that required retreatment occurred in 22. Treatment-free survival (TFS) was significantly shorter in patients with NLR ≥2.21 (<i>P</i> = 0.0010). Multivariate Cox proportional hazards regression showed that NLR and neurofibromatosis type 2 were independent predictors of retreatment (<i>P</i> = 0.0423 and 0.0043, respectively). TFS was significantly shorter in patients with NLR ≥2.21 in the following subgroups: sporadic schwannoma, primary schwannoma, schwannoma ≥30 mm in size, subtotal resection, vestibular schwannoma, and postoperative recurrence.<h4>Conclusions</h4>Preoperative NLR ≥2.21 before surgery was significantly associated with retreatment after schwannoma resection. NLR may be a novel predictor of retreatment and assist surgeons in preoperative surgical decision making.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-05T13:20:49.866Z","creation":"2025-04-05T13:20:49.866Z"},"accession":"S-EPMC9950385","cross_references":{"pubmed":["36845735"],"doi":["10.3389/fonc.2023.1099384"]}}