{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wroblewski EE"],"funding":["NIAID NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health"],"pagination":["1033"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9950436"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["The malaria parasite Plasmodium falciparum causes substantial human mortality, primarily in equatorial Africa. Enriched in affected African populations, the B*53 variant of HLA-B, a cell surface protein that presents peptide antigens to cytotoxic lymphocytes, confers protection against severe malaria. Gorilla, chimpanzee, and bonobo are humans' closest living relatives. These African apes have HLA-B orthologs and are infected by parasites in the same subgenus (Laverania) as P. falciparum, but the consequences of these infections are unclear. Laverania parasites infect bonobos (Pan paniscus) at only one (TL2) of many sites sampled across their range. TL2 spans the Lomami River and has genetically divergent subpopulations of bonobos on each side. Papa-B, the bonobo ortholog of HLA-B, includes variants having a B*53-like (B07) peptide-binding supertype profile. Here we show that B07 Papa-B occur at high frequency in TL2 bonobos and that malaria appears to have independently selected for different B07 alleles in the two subpopulations."],"journal":["Nature communications"],"pubmed_title":["Malaria-driven adaptation of MHC class I in wild bonobo populations."],"pmcid":["PMC9950436"],"funding_grant_id":["R01 AI120810","R01 AI024258","P30 AI045008","R01 AI 058715","R01 AI091595","R37 AI050529","R01 AI058715","R01 AI24258","R37 AI 050529","P30 AI 045008","R01 AI 120810","R01 AI 091595"],"pubmed_authors":["Connell AJ","Sanz CM","Heisel SE","Wroblewski EE","Parham P","Peeters M","Liu W","Morgan DB","Bertolani P","Hart TB","Li Y","Ndjango JN","Hahn BH","Guethlein LA","Sharp PM","Anderson AG","Hart JA"],"additional_accession":[]},"is_claimable":false,"name":"Malaria-driven adaptation of MHC class I in wild bonobo populations.","description":"The malaria parasite Plasmodium falciparum causes substantial human mortality, primarily in equatorial Africa. Enriched in affected African populations, the B*53 variant of HLA-B, a cell surface protein that presents peptide antigens to cytotoxic lymphocytes, confers protection against severe malaria. Gorilla, chimpanzee, and bonobo are humans' closest living relatives. These African apes have HLA-B orthologs and are infected by parasites in the same subgenus (Laverania) as P. falciparum, but the consequences of these infections are unclear. Laverania parasites infect bonobos (Pan paniscus) at only one (TL2) of many sites sampled across their range. TL2 spans the Lomami River and has genetically divergent subpopulations of bonobos on each side. Papa-B, the bonobo ortholog of HLA-B, includes variants having a B*53-like (B07) peptide-binding supertype profile. Here we show that B07 Papa-B occur at high frequency in TL2 bonobos and that malaria appears to have independently selected for different B07 alleles in the two subpopulations.","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-28T19:01:07.998Z","creation":"2025-02-19T00:13:23.09Z"},"accession":"S-EPMC9950436","cross_references":{"pubmed":["36823144"],"doi":["10.1038/s41467-023-36623-9"]}}