{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang K"],"funding":["National Science Foundation of China | National Natural Science Foundation of China-Yunnan Joint Fund (NSFC-Yunnan Joint Fund)","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["1011"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9950448"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses, we show a heterogeneity between metabolite and transcript profiles. Specifically, the level of serine in hepatocellular carcinoma (HCC) tissues is increased, whereas the expression of phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme in serine biosynthesis pathway, is markedly downregulated. Interestingly, the increased serine level is obtained by enhanced PHGDH catalytic activity due to protein arginine methyltransferase 1 (PRMT1)-mediated methylation of PHGDH at arginine 236. PRMT1-mediated PHGDH methylation and activation potentiates serine synthesis, ameliorates oxidative stress, and pr"],"journal":["Nature communications"],"pubmed_title":["PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma."],"pmcid":["PMC9950448"],"funding_grant_id":["82002963","82273122","82073081","81872277","82130082","81790251","81821002"],"pubmed_authors":["Peng Y","Huang C","Fu S","Chen HN","Dong L","Wei X","Wang K","Shen G","Wang M","Dai L","Nice EC","Luo L","Wang Z","Wu X"],"additional_accession":[]},"is_claimable":false,"name":"PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma.","description":"Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, using integrative metabolomics and transcriptomics analyses, we show a heterogeneity between metabolite and transcript profiles. Specifically, the level of serine in hepatocellular carcinoma (HCC) tissues is increased, whereas the expression of phosphoglycerate dehydrogenase (PHGDH), the first rate-limiting enzyme in serine biosynthesis pathway, is markedly downregulated. Interestingly, the increased serine level is obtained by enhanced PHGDH catalytic activity due to protein arginine methyltransferase 1 (PRMT1)-mediated methylation of PHGDH at arginine 236. PRMT1-mediated PHGDH methylation and activation potentiates serine synthesis, ameliorates oxidative stress, and pr","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-29T19:42:53.08Z","creation":"2025-05-29T19:42:53.08Z"},"accession":"S-EPMC9950448","cross_references":{"pubmed":["36823188"],"doi":["10.1038/s41467-023-36708-5"]}}