{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Chen K"],"pubmed_abstract":["<i>Aeromonas hydrophila</i> is a significant pathogen to freshwater farmed animals, and antibiotics are usually used to control the bacterial septicemia caused by <i>A. hydrophila</i>. Due to the severe situation of development and spread of antibiotic resistance, there are stricter restrictions on antibiotics used in aquaculture. To evaluate the feasibility of glycyrrhetinic acid β (GA) as an alternative therapy against bacterial infection, in this study, an <i>A. hydrophila</i> isolated from diseased fish is used to test the antibacterial, anti-virulence activity and therapeutic effect of GA <i>in vitro</i> and <i>in vivo</i>, respectively. Results showed that GA did not affect the growth of <i>A. hydrophila in vitro</i>, while it could down-regulate (<i>p</i> < 0.05) the mRNA expression"],"journal":["Frontiers in microbiology"],"pagination":["1043838"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9950564"],"repository":["biostudies-literature"],"pubmed_title":["Effects of glycyrrhetinic acid β on growth and virulence of <i>Aeromonas hydrophila</i>."],"pmcid":["PMC9950564"],"pubmed_authors":["Bing X","Chen K","Xie J","Xi B","Qin T","Pan L"],"additional_accession":[]},"is_claimable":false,"name":"Effects of glycyrrhetinic acid β on growth and virulence of <i>Aeromonas hydrophila</i>.","description":"<i>Aeromonas hydrophila</i> is a significant pathogen to freshwater farmed animals, and antibiotics are usually used to control the bacterial septicemia caused by <i>A. hydrophila</i>. Due to the severe situation of development and spread of antibiotic resistance, there are stricter restrictions on antibiotics used in aquaculture. To evaluate the feasibility of glycyrrhetinic acid β (GA) as an alternative therapy against bacterial infection, in this study, an <i>A. hydrophila</i> isolated from diseased fish is used to test the antibacterial, anti-virulence activity and therapeutic effect of GA <i>in vitro</i> and <i>in vivo</i>, respectively. Results showed that GA did not affect the growth of <i>A. hydrophila in vitro</i>, while it could down-regulate (<i>p</i> < 0.05) the mRNA expression","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-22T03:40:42.454Z","creation":"2025-04-05T20:44:41.858Z"},"accession":"S-EPMC9950564","cross_references":{"pubmed":["36846766"],"doi":["10.3389/fmicb.2023.1043838"]}}