biostudies-literatureUnknown14Chen K<i>Aeromonas hydrophila</i> is a significant pathogen to freshwater farmed animals, and antibiotics are usually used to control the bacterial septicemia caused by <i>A. hydrophila</i>. Due to the severe situation of development and spread of antibiotic resistance, there are stricter restrictions on antibiotics used in aquaculture. To evaluate the feasibility of glycyrrhetinic acid β (GA) as an alternative therapy against bacterial infection, in this study, an <i>A. hydrophila</i> isolated from diseased fish is used to test the antibacterial, anti-virulence activity and therapeutic effect of GA <i>in vitro</i> and <i>in vivo</i>, respectively. Results showed that GA did not affect the growth of <i>A. hydrophila in vitro</i>, while it could down-regulate (<i>p</i> < 0.05) the mRNA expressionFrontiers in microbiology1043838https://www.ebi.ac.uk/biostudies/studies/S-EPMC9950564biostudies-literatureEffects of glycyrrhetinic acid β on growth and virulence of <i>Aeromonas hydrophila</i>.PMC9950564Bing XChen KXie JXi BQin TPan LfalseEffects of glycyrrhetinic acid β on growth and virulence of <i>Aeromonas hydrophila</i>.<i>Aeromonas hydrophila</i> is a significant pathogen to freshwater farmed animals, and antibiotics are usually used to control the bacterial septicemia caused by <i>A. hydrophila</i>. Due to the severe situation of development and spread of antibiotic resistance, there are stricter restrictions on antibiotics used in aquaculture. To evaluate the feasibility of glycyrrhetinic acid β (GA) as an alternative therapy against bacterial infection, in this study, an <i>A. hydrophila</i> isolated from diseased fish is used to test the antibacterial, anti-virulence activity and therapeutic effect of GA <i>in vitro</i> and <i>in vivo</i>, respectively. Results showed that GA did not affect the growth of <i>A. hydrophila in vitro</i>, while it could down-regulate (<i>p</i> < 0.05) the mRNA expression2023-01-01T00:00:00Z20232025-04-22T03:40:42.454Z2025-04-05T20:44:41.858ZS-EPMC99505643684676610.3389/fmicb.2023.1043838