biostudies-literatureZhao JCapital's Funds for Health Improvement and Research of ChinaNatural Science Foundation of Xiamen CityCapital’s Funds for Health Improvement and Research of China19https://www.ebi.ac.uk/biostudies/studies/S-EPMC9950708biostudies-literatureUnknown18(1)<h4>Background</h4>Non-alcoholic steatohepatitis (NASH) had not yet been approved therapy. Electro-acupuncture (EA) has been reported to have potential efficacy. However, high-quality clinical evidence was still lacking.<h4>Methods</h4>NASH patients were randomized and allocated to either sham acupuncture (SA) or EA group in a 1:1 ratio, with the patient blinded. Each patient received 36 sessions of SA or EA treatment over 12 weeks, followed by additional 4 weeks. The primary outcome was the changes in relative liver fat content measured by magnetic resonance imaging proton density fat fraction (MRI-PDFF).<h4>Results</h4>A total of 60 patients were enrolled. From baseline to week 12, the reduction of relative liver fat content measured by MRI-PDFF in the EA group (- 33.6%, quantile range: Chinese medicineElectro-acupuncture reduced steatosis on MRI-PDFF in patients with non-alcoholic steatohepatitis: a randomized controlled pilot clinical trial.PMC99507082022-1-20212022-2-2021382130018Wu LLi JCao DDu YTong XZhao XJia JZhang WRen HWang QXu SOu XHan CZhao JDuan WYou HfalseElectro-acupuncture reduced steatosis on MRI-PDFF in patients with non-alcoholic steatohepatitis: a randomized controlled pilot clinical trial.<h4>Background</h4>Non-alcoholic steatohepatitis (NASH) had not yet been approved therapy. Electro-acupuncture (EA) has been reported to have potential efficacy. However, high-quality clinical evidence was still lacking.<h4>Methods</h4>NASH patients were randomized and allocated to either sham acupuncture (SA) or EA group in a 1:1 ratio, with the patient blinded. Each patient received 36 sessions of SA or EA treatment over 12 weeks, followed by additional 4 weeks. The primary outcome was the changes in relative liver fat content measured by magnetic resonance imaging proton density fat fraction (MRI-PDFF).<h4>Results</h4>A total of 60 patients were enrolled. From baseline to week 12, the reduction of relative liver fat content measured by MRI-PDFF in the EA group (- 33.6%, quantile range: 2023-01-01T00:00:00Z2023 Feb2025-04-05T13:20:24.378Z2025-02-18T23:58:02.017ZS-EPMC99507083682922910.1186/s13020-023-00724-w