{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Williams GP"],"funding":["NIAID NIH HHS","Aligning Science Across Parkinson’s","NINDS NIH HHS","National Institutes of Health","JPB Foundation"],"pagination":["120510"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9950758"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["444"],"pubmed_abstract":["<h4>Background and objectives</h4>Parkinson's disease (PD) is associated with a heightened inflammatory state, including activated T cells. However, it is unclear whether these PD T cell responses are antigen specific or more indicative of generalized hyperresponsiveness. Our objective was to measure and compare antigen-specific T cell responses directed towards antigens derived from commonly encountered human pathogens/vaccines in patients with PD and age-matched healthy controls (HC).<h4>Methods</h4>Peripheral blood mononuclear cells (PBMCs) from 20 PD patients and 19 age-matched HCs were screened. Antigen specific T cell responses were measured by flow cytometry using a combination of the activation induced marker (AIM) assay and intracellular cytokine staining.<h4>Results</h4>Here we s"],"journal":["Journal of the neurological sciences"],"pubmed_title":["Unaltered T cell responses to common antigens in individuals with Parkinson's disease."],"pmcid":["PMC9950758"],"funding_grant_id":["P50NS108675","ASAP-000375","R01 NS095435","P50 NS108675","T32AI125179","T32 AI125179"],"pubmed_authors":["Goldman JG","Mateus J","Sette A","Williams GP","Frazier A","Sulzer D","Grifoni A","Alcalay RN","Weiskopf D","Litvan I","da Silva Antunes R","Standaert DG","Muskat K","Lindestam Arlehamn CS","Amara AW","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"Unaltered T cell responses to common antigens in individuals with Parkinson's disease.","description":"<h4>Background and objectives</h4>Parkinson's disease (PD) is associated with a heightened inflammatory state, including activated T cells. However, it is unclear whether these PD T cell responses are antigen specific or more indicative of generalized hyperresponsiveness. Our objective was to measure and compare antigen-specific T cell responses directed towards antigens derived from commonly encountered human pathogens/vaccines in patients with PD and age-matched healthy controls (HC).<h4>Methods</h4>Peripheral blood mononuclear cells (PBMCs) from 20 PD patients and 19 age-matched HCs were screened. Antigen specific T cell responses were measured by flow cytometry using a combination of the activation induced marker (AIM) assay and intracellular cytokine staining.<h4>Results</h4>Here we s","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-28T12:56:52.641Z","creation":"2025-02-19T04:20:53.039Z"},"accession":"S-EPMC9950758","cross_references":{"pubmed":["36495691"],"doi":["10.1016/j.jns.2022.120510"]}}