biostudies-literatureWilliams GPNIAID NIH HHSAligning Science Across Parkinson’sNINDS NIH HHSNational Institutes of HealthJPB Foundation120510https://www.ebi.ac.uk/biostudies/studies/S-EPMC9950758biostudies-literatureUnknown444<h4>Background and objectives</h4>Parkinson's disease (PD) is associated with a heightened inflammatory state, including activated T cells. However, it is unclear whether these PD T cell responses are antigen specific or more indicative of generalized hyperresponsiveness. Our objective was to measure and compare antigen-specific T cell responses directed towards antigens derived from commonly encountered human pathogens/vaccines in patients with PD and age-matched healthy controls (HC).<h4>Methods</h4>Peripheral blood mononuclear cells (PBMCs) from 20 PD patients and 19 age-matched HCs were screened. Antigen specific T cell responses were measured by flow cytometry using a combination of the activation induced marker (AIM) assay and intracellular cytokine staining.<h4>Results</h4>Here we sJournal of the neurological sciencesUnaltered T cell responses to common antigens in individuals with Parkinson's disease.PMC9950758P50NS108675ASAP-000375R01 NS095435P50 NS108675T32AI125179T32 AI125179Goldman JGMateus JSette AWilliams GPFrazier ASulzer DGrifoni AAlcalay RNWeiskopf DLitvan Ida Silva Antunes RStandaert DGMuskat KLindestam Arlehamn CSAmara AWXu YfalseUnaltered T cell responses to common antigens in individuals with Parkinson's disease.<h4>Background and objectives</h4>Parkinson's disease (PD) is associated with a heightened inflammatory state, including activated T cells. However, it is unclear whether these PD T cell responses are antigen specific or more indicative of generalized hyperresponsiveness. Our objective was to measure and compare antigen-specific T cell responses directed towards antigens derived from commonly encountered human pathogens/vaccines in patients with PD and age-matched healthy controls (HC).<h4>Methods</h4>Peripheral blood mononuclear cells (PBMCs) from 20 PD patients and 19 age-matched HCs were screened. Antigen specific T cell responses were measured by flow cytometry using a combination of the activation induced marker (AIM) assay and intracellular cytokine staining.<h4>Results</h4>Here we s2023-01-01T00:00:00Z2023 Jan2026-05-28T12:56:52.641Z2025-02-19T04:20:53.039ZS-EPMC99507583649569110.1016/j.jns.2022.120510