biostudies-literatureLian IBMedical Research Councile13569https://www.ebi.ac.uk/biostudies/studies/S-EPMC9950832biostudies-literatureUnknown9(2)<h4>Background</h4>Previous studies suggested that vasomotor symptoms were associated with an increasing risk of coronary heart diseases (CHD) but not clear with menopausal symptoms other than vasomotor symptoms. Given the heterogeneity and interrelationship among menopausal symptoms, it is not easy to make causal inferences based on observational studies. We performed a Mendelian randomization (MR) to investigate the association of individual non-vasomotor menopausal symptoms and the risk of CHDs.<h4>Methods</h4>A sample of 177,497 British women aged ≥51 years old (average age at menopause) without related cardiovascular diseases from the UK biobank is selected as our study population. Non-vasomotor menopausal symptoms, including anxiety, nervous, insomnia, urinary tract infection, fatiguHeliyonEffects of insomnia and non-vasomotor menopausal symptoms on coronary heart disease risk: a mendelian randomization study.PMC9950832MC_QA137853Lian IBChang CCFann CSJSie JJHuang CHfalseEffects of insomnia and non-vasomotor menopausal symptoms on coronary heart disease risk: a mendelian randomization study.<h4>Background</h4>Previous studies suggested that vasomotor symptoms were associated with an increasing risk of coronary heart diseases (CHD) but not clear with menopausal symptoms other than vasomotor symptoms. Given the heterogeneity and interrelationship among menopausal symptoms, it is not easy to make causal inferences based on observational studies. We performed a Mendelian randomization (MR) to investigate the association of individual non-vasomotor menopausal symptoms and the risk of CHDs.<h4>Methods</h4>A sample of 177,497 British women aged ≥51 years old (average age at menopause) without related cardiovascular diseases from the UK biobank is selected as our study population. Non-vasomotor menopausal symptoms, including anxiety, nervous, insomnia, urinary tract infection, fatigu2023-01-01T00:00:00Z2023 Feb2026-03-27T16:47:06.818Z2025-04-05T20:45:22.771ZS-EPMC99508323684668110.1016/j.heliyon.2023.e13569