{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(3)"],"submitter":["Xiao M"],"pubmed_abstract":["<h4>Background</h4>Jian Pi Sheng Sui Gao (JPSSG), a Chinese traditional herbal paste, possesses certain efficacy in patients with cancer-related fatigue (CRF); however, its related mechanism remains unclear. Hence, network pharmacology analysis, followed by <i>in vivo</i> and <i>in vitro</i> experiments were conducted in this study with the aim to evaluate the effect of JPSSG on CRF and clarify its potential mechanism.<h4>Methods</h4>Network pharmacology analysis was performed. Subsequently, 12 mice were injected with CT26 cells to establish CRF mouse models and randomly divided into a model group (n=6) and JPSSG group (n=6); meanwhile, another 6 normal mice served as a control group. Then, 3.0 g/kg JPSSG was given to mice in JPSSG group for 15 days, while mice in the n control and model g"],"journal":["Annals of translational medicine"],"pagination":["156"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9951005"],"repository":["biostudies-literature"],"pubmed_title":["Jian Pi Sheng Sui Gao (JPSSG) alleviation of skeletal myoblast cell apoptosis, oxidative stress, and mitochondrial dysfunction to improve cancer-related fatigue in an AMPK-SIRT1- and HIF-1-dependent manner."],"pmcid":["PMC9951005"],"pubmed_authors":["Jiang J","Yang Z","Xiao M","Li Z","Zhu Y","Zhang J","Guo W","Zhang C","Lin L","Shao C"],"additional_accession":[]},"is_claimable":false,"name":"Jian Pi Sheng Sui Gao (JPSSG) alleviation of skeletal myoblast cell apoptosis, oxidative stress, and mitochondrial dysfunction to improve cancer-related fatigue in an AMPK-SIRT1- and HIF-1-dependent manner.","description":"<h4>Background</h4>Jian Pi Sheng Sui Gao (JPSSG), a Chinese traditional herbal paste, possesses certain efficacy in patients with cancer-related fatigue (CRF); however, its related mechanism remains unclear. Hence, network pharmacology analysis, followed by <i>in vivo</i> and <i>in vitro</i> experiments were conducted in this study with the aim to evaluate the effect of JPSSG on CRF and clarify its potential mechanism.<h4>Methods</h4>Network pharmacology analysis was performed. Subsequently, 12 mice were injected with CT26 cells to establish CRF mouse models and randomly divided into a model group (n=6) and JPSSG group (n=6); meanwhile, another 6 normal mice served as a control group. Then, 3.0 g/kg JPSSG was given to mice in JPSSG group for 15 days, while mice in the n control and model g","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-22T03:35:45.583Z","creation":"2025-04-05T20:43:14.665Z"},"accession":"S-EPMC9951005","cross_references":{"pubmed":["36846003"],"doi":["10.21037/atm-22-6611"]}}