{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(7)"],"submitter":["Iqbal MN"],"funding":["Vetenskapsr?det"],"pubmed_abstract":["Mesoporous silica particles (MSPs) can be used as food additives, clinically for therapeutic applications, or as oral delivery vehicles. It has also been discussed to be used for a number of novel applications including treatment for diabetes and obesity. However, a major question for their possible usage has been if these particles persist structurally and retain their effect when passing through the gastrointestinal tract (GIT). A substantial breaking down of the particles could reduce function and be clinically problematic for safety issues. Hence, we investigated the biostability of MSPs of the SBA-15 kind prepared at large scales (100 and 1000 L). The MSPs were orally administered in a murine model and clinically in humans. A joint extraction and calcination method was developed to re"],"journal":["ACS applied materials & interfaces"],"pagination":["9542-9553"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9951217"],"repository":["biostudies-literature"],"pubmed_title":["Mesoporous Silica Particles Retain Their Structure and Function while Passing through the Gastrointestinal Tracts of Mice and Humans."],"pmcid":["PMC9951217"],"pubmed_authors":["Akhtar F","Bengtsson T","Iqbal MN","Ciurans-Oset M","Hedin N","Robert-Nicoud G"],"additional_accession":[]},"is_claimable":false,"name":"Mesoporous Silica Particles Retain Their Structure and Function while Passing through the Gastrointestinal Tracts of Mice and Humans.","description":"Mesoporous silica particles (MSPs) can be used as food additives, clinically for therapeutic applications, or as oral delivery vehicles. It has also been discussed to be used for a number of novel applications including treatment for diabetes and obesity. However, a major question for their possible usage has been if these particles persist structurally and retain their effect when passing through the gastrointestinal tract (GIT). A substantial breaking down of the particles could reduce function and be clinically problematic for safety issues. Hence, we investigated the biostability of MSPs of the SBA-15 kind prepared at large scales (100 and 1000 L). The MSPs were orally administered in a murine model and clinically in humans. A joint extraction and calcination method was developed to re","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-28T08:15:22.588Z","creation":"2024-11-07T06:05:22.592Z"},"accession":"S-EPMC9951217","cross_references":{"pubmed":["36731867"],"doi":["10.1021/acsami.2c16710"]}}