{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang S"],"funding":["Shanghai Science and Technology Committee Rising-Star Program","Shanghai Science and Technology","National Natural Science Foundation of China","Basic Research Program of Shanghai Municipal Government","Qingnian Yingcai Qihang Plan of Shanghai University"],"pagination":["e2206009"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9951320"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["Covalent organic frameworks (COFs) have attracted increasing attention for biomedical applications. COFs-based nanosensitizers with uniform nanoscale morphology and tumor-specific curative effects are in high demand; however, their synthesis is yet challenging. In this study, distinct COF nanobowls are synthesized in a controlled manner and engineered as activatable nanosensitizers with tumor-specific sonodynamic activity. High crystallinity ensures an ordered porous structure of COF nanobowls for the efficient loading of the small-molecule sonosensitizer rose bengal (RB). To circumvent non-specific damage to normal tissues, the sonosensitization effect is specifically inhibited by the in situ growth of manganese oxide (MnO<sub>x</sub> ) on RB-loaded COFs. Upon reaction with tumor-overexpr"],"journal":["Advanced science (Weinheim, Baden-Wurttemberg, Germany)"],"pubmed_title":["Covalent Organic Framework Nanobowls as Activatable Nanosensitizers for Tumor-Specific and Ferroptosis-Augmented Sonodynamic Therapy."],"pmcid":["PMC9951320"],"funding_grant_id":["21010500100","22142202200","52072393","52102350","21QA1403100","21JC1406002","22DZ2204700","22140901700"],"pubmed_authors":["Chen L","Xia S","Chen Y","Zhang S","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"Covalent Organic Framework Nanobowls as Activatable Nanosensitizers for Tumor-Specific and Ferroptosis-Augmented Sonodynamic Therapy.","description":"Covalent organic frameworks (COFs) have attracted increasing attention for biomedical applications. COFs-based nanosensitizers with uniform nanoscale morphology and tumor-specific curative effects are in high demand; however, their synthesis is yet challenging. In this study, distinct COF nanobowls are synthesized in a controlled manner and engineered as activatable nanosensitizers with tumor-specific sonodynamic activity. High crystallinity ensures an ordered porous structure of COF nanobowls for the efficient loading of the small-molecule sonosensitizer rose bengal (RB). To circumvent non-specific damage to normal tissues, the sonosensitization effect is specifically inhibited by the in situ growth of manganese oxide (MnO<sub>x</sub> ) on RB-loaded COFs. Upon reaction with tumor-overexpr","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-04-08T23:16:52.456Z","creation":"2025-04-05T20:44:56.607Z"},"accession":"S-EPMC9951320","cross_references":{"pubmed":["36594611"],"doi":["10.1002/advs.202206009"]}}