biostudies-literatureZhang SShanghai Science and Technology Committee Rising-Star ProgramShanghai Science and TechnologyNational Natural Science Foundation of ChinaBasic Research Program of Shanghai Municipal GovernmentQingnian Yingcai Qihang Plan of Shanghai Universitye2206009https://www.ebi.ac.uk/biostudies/studies/S-EPMC9951320biostudies-literatureUnknown10(6)Covalent organic frameworks (COFs) have attracted increasing attention for biomedical applications. COFs-based nanosensitizers with uniform nanoscale morphology and tumor-specific curative effects are in high demand; however, their synthesis is yet challenging. In this study, distinct COF nanobowls are synthesized in a controlled manner and engineered as activatable nanosensitizers with tumor-specific sonodynamic activity. High crystallinity ensures an ordered porous structure of COF nanobowls for the efficient loading of the small-molecule sonosensitizer rose bengal (RB). To circumvent non-specific damage to normal tissues, the sonosensitization effect is specifically inhibited by the in situ growth of manganese oxide (MnO_x ) on RB-loaded COFs. Upon reaction with tumor-overexprAdvanced science (Weinheim, Baden-Wurttemberg, Germany)Covalent Organic Framework Nanobowls as Activatable Nanosensitizers for Tumor-Specific and Ferroptosis-Augmented Sonodynamic Therapy.PMC99513202101050010022142202200520723935210235021QA140310021JC140600222DZ220470022140901700Chen LXia SChen YZhang SZhou JfalseCovalent Organic Framework Nanobowls as Activatable Nanosensitizers for Tumor-Specific and Ferroptosis-Augmented Sonodynamic Therapy.Covalent organic frameworks (COFs) have attracted increasing attention for biomedical applications. COFs-based nanosensitizers with uniform nanoscale morphology and tumor-specific curative effects are in high demand; however, their synthesis is yet challenging. In this study, distinct COF nanobowls are synthesized in a controlled manner and engineered as activatable nanosensitizers with tumor-specific sonodynamic activity. High crystallinity ensures an ordered porous structure of COF nanobowls for the efficient loading of the small-molecule sonosensitizer rose bengal (RB). To circumvent non-specific damage to normal tissues, the sonosensitization effect is specifically inhibited by the in situ growth of manganese oxide (MnO_x ) on RB-loaded COFs. Upon reaction with tumor-overexpr2023-01-01T00:00:00Z2023 Feb2026-04-08T23:16:52.456Z2025-04-05T20:44:56.607ZS-EPMC99513203659461110.1002/advs.202206009