biostudies-literatureZhai KFundamental Research Funds for the Central Universities, Sun Yat-sen UniversityFundamental Research Funds for or the Central Universities, the Sun Yat-sen UniversityGuangdong Basic and Applied Basic Research FoundationNational Natural Science Foundation of ChinaGuangzhou Science and Technology Programmee2205632https://www.ebi.ac.uk/biostudies/studies/S-EPMC9951583biostudies-literatureUnknown10(6)Stretchable hydrogel-based strain sensors suffer from limited sensitivity, which urgently requires further breakthroughs for precise and stable human-computer interaction. Here, an efficient microstructural engineering strategy is proposed to significantly enhance the sensitivity of hydrogel-based strain sensors by sandwiching an emulsion-polymerized polyacrylamide organohydrogel microsphere membrane between two Ecoflex films, which are accompanied by crack generation and propagation effects upon stretching. Consequently, the as-developed strain sensor exhibits ultrahigh sensitivity (gauge factor (GF) of 1275), wide detection range (100% strain), low hysteresis, ultralow detection limit (0.05% strain), good fatigue resistance, and low fabrication cost. In addition, the sensor features goodAdvanced science (Weinheim, Baden-Wurttemberg, Germany)High-Performance Strain Sensors Based on Organohydrogel Microsphere Film for Wearable Human-Computer Interfacing.PMC99515836180152522dfx022020A15150106932021A151511026920190701003822lgqb1781974139Tao KWu ZYang BRWu JLi CXie XZhai KWang HDing QDing MfalseHigh-Performance Strain Sensors Based on Organohydrogel Microsphere Film for Wearable Human-Computer Interfacing.Stretchable hydrogel-based strain sensors suffer from limited sensitivity, which urgently requires further breakthroughs for precise and stable human-computer interaction. Here, an efficient microstructural engineering strategy is proposed to significantly enhance the sensitivity of hydrogel-based strain sensors by sandwiching an emulsion-polymerized polyacrylamide organohydrogel microsphere membrane between two Ecoflex films, which are accompanied by crack generation and propagation effects upon stretching. Consequently, the as-developed strain sensor exhibits ultrahigh sensitivity (gauge factor (GF) of 1275), wide detection range (100% strain), low hysteresis, ultralow detection limit (0.05% strain), good fatigue resistance, and low fabrication cost. In addition, the sensor features good2023-01-01T00:00:00Z2023 Feb2025-04-05T13:21:29.684Z2025-04-05T13:21:29.684ZS-EPMC99515833656313610.1002/advs.202205632