{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Franco-Trepat E"],"funding":["Spanish Ministry of Science via FECYT","A.J.-M.","Spanish Ministry of Universities","R.G.","E.F.-T.","Mutua Madrileña Foundation","V.L.-L.","European Union’s Horizon Europe research and innovation programme","M.L.-F.","Instituto de Salud Carlos III & FEDER","S.B.B.","the Instituto de Salud Carlos III (ISCIII) &amp;amp; Fondo Europeo de Desarrollo Regional (FEDER) via ”Fondo de Investigación Sanitaria”","European Union's Horizon Europe research and innovation programme: ENDOTARGET","A.C.-G.","A.L-I.","Sociedad Española de Reumatologia (SER)—Fundación Española de Reumatologia (FER)","A.A.-P.","Fundación Española de Reumatologia (FER)","A.P.-P.","M.G.-F.","M.P.-R.","Spanish Ministry of Universities & European Union through NextGenerationEU","Fundación Mutua Madrileña","J.P.C-C.","Ministry of Universities","European Union through NextGenerationEU","the Spanish Ministry of Science via FECYT"],"pagination":["371"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9952103"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(2)"],"pubmed_abstract":["Osteoarthritis (OA) is hallmarked as a silent progressive rheumatic disease of the whole joint. The accumulation of inflammatory and catabolic factors such as IL6, TNFα, and COX2 drives the OA pathophysiology into cartilage degradation, synovia inflammation, and bone destruction. There is no clinical available OA treatment. Although traditional ayurvedic medicine has been using <i>Boswellia serrata</i> extracts (BSE) as an antirheumatic treatment for a millennium, none of the BSE components have been clinically approved. Recently, β boswellic acid (BBA) has been shown to reduce in vivo OA-cartilage loss through an unknown mechanism. We used computational pharmacology, proteomics, transcriptomics, and metabolomics to present solid evidence of BBA therapeutic properties in mouse and primary "],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["β Boswellic Acid Blocks Articular Innate Immune Responses: An In Silico and In Vitro Approach to Traditional Medicine."],"pmcid":["PMC9952103"],"funding_grant_id":["PRECIPITA PR250","MMA 2020","PI19/01446","RSU.UDC.MS06","UDC Margarita Salas RSU.UDC.MS06","CM20/00186","FPU17/01706","FI20/00210","CPII20/00026","PI16/01870","PT20/00009","CP15/00007","101095084","Búsqueda de nuevos fármacos bloqueantes de la inflamación asociada a TLR4 en condrocitos humanos Artrósicos (Artrosis 2019)","IDIS 2019","RD21/0002/0025","MMA 2018"],"pubmed_authors":["Franco-Trepat E","Crespo-Golmar A","Jorge-Mora A","Lois Iglesias A","Guillan-Fresco M","Pazos-Perez A","Gomez R","Ceron-Carrasco JP","Belen Bravo S","Lopez-Fagundez M","Lopez-Lopez V","Alonso-Perez A"],"additional_accession":[]},"is_claimable":false,"name":"β Boswellic Acid Blocks Articular Innate Immune Responses: An In Silico and In Vitro Approach to Traditional Medicine.","description":"Osteoarthritis (OA) is hallmarked as a silent progressive rheumatic disease of the whole joint. The accumulation of inflammatory and catabolic factors such as IL6, TNFα, and COX2 drives the OA pathophysiology into cartilage degradation, synovia inflammation, and bone destruction. There is no clinical available OA treatment. Although traditional ayurvedic medicine has been using <i>Boswellia serrata</i> extracts (BSE) as an antirheumatic treatment for a millennium, none of the BSE components have been clinically approved. Recently, β boswellic acid (BBA) has been shown to reduce in vivo OA-cartilage loss through an unknown mechanism. We used computational pharmacology, proteomics, transcriptomics, and metabolomics to present solid evidence of BBA therapeutic properties in mouse and primary ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-04-08T13:29:59.825Z","creation":"2024-12-04T13:09:44.624Z"},"accession":"S-EPMC9952103","cross_references":{"pubmed":["36829930"],"doi":["10.3390/antiox12020371"]}}