{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(2)"],"submitter":["Chiusaroli L"],"pubmed_abstract":["<h4>Background</h4>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), methicillin-resistant coagulase-negative <i>Staphylococci</i> (MR-CoNS), and vancomycin-resistant <i>Enterococci</i> (VRE) are increasing worldwide and represent a threat for the limited treatment options in pediatric patients and neonates compared to adults. Recommendations in pediatrics are mainly extrapolated from adults' studies.<h4>Methods</h4>A literature search for the treatment of these pathogens in children (<18 years old) was conducted in Embase, MEDLINE, and Cochrane Library. Studies reporting data on single-patient-level outcomes related to a specific antibiotic treatment for multidrug resistant (MDR) Gram-positive bacterial infection in children were included. Studies reporting data from adults and c"],"journal":["Antibiotics (Basel, Switzerland)"],"pagination":["261"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9952189"],"repository":["biostudies-literature"],"pubmed_title":["Therapeutic Options and Outcomes for the Treatment of Children with Gram-Positive Bacteria with Resistances of Concern: A Systematic Review."],"pmcid":["PMC9952189"],"pubmed_authors":["Barbieri E","Chiusaroli L","Di Chiara C","Mengato D","Rulli L","Liberati C","De Pieri M","Dona D","Giaquinto C"],"additional_accession":[]},"is_claimable":false,"name":"Therapeutic Options and Outcomes for the Treatment of Children with Gram-Positive Bacteria with Resistances of Concern: A Systematic Review.","description":"<h4>Background</h4>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), methicillin-resistant coagulase-negative <i>Staphylococci</i> (MR-CoNS), and vancomycin-resistant <i>Enterococci</i> (VRE) are increasing worldwide and represent a threat for the limited treatment options in pediatric patients and neonates compared to adults. Recommendations in pediatrics are mainly extrapolated from adults' studies.<h4>Methods</h4>A literature search for the treatment of these pathogens in children (<18 years old) was conducted in Embase, MEDLINE, and Cochrane Library. Studies reporting data on single-patient-level outcomes related to a specific antibiotic treatment for multidrug resistant (MDR) Gram-positive bacterial infection in children were included. Studies reporting data from adults and c","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-05-29T19:43:00.486Z","creation":"2025-05-29T19:43:00.486Z"},"accession":"S-EPMC9952189","cross_references":{"pubmed":["36830174"],"doi":["10.3390/antibiotics12020261"]}}