biostudies-literatureUnknown12(2)Chiusaroli L<h4>Background</h4>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), methicillin-resistant coagulase-negative <i>Staphylococci</i> (MR-CoNS), and vancomycin-resistant <i>Enterococci</i> (VRE) are increasing worldwide and represent a threat for the limited treatment options in pediatric patients and neonates compared to adults. Recommendations in pediatrics are mainly extrapolated from adults' studies.<h4>Methods</h4>A literature search for the treatment of these pathogens in children (<18 years old) was conducted in Embase, MEDLINE, and Cochrane Library. Studies reporting data on single-patient-level outcomes related to a specific antibiotic treatment for multidrug resistant (MDR) Gram-positive bacterial infection in children were included. Studies reporting data from adults and cAntibiotics (Basel, Switzerland)261https://www.ebi.ac.uk/biostudies/studies/S-EPMC9952189biostudies-literatureTherapeutic Options and Outcomes for the Treatment of Children with Gram-Positive Bacteria with Resistances of Concern: A Systematic Review.PMC9952189Barbieri EChiusaroli LDi Chiara CMengato DRulli LLiberati CDe Pieri MDona DGiaquinto CfalseTherapeutic Options and Outcomes for the Treatment of Children with Gram-Positive Bacteria with Resistances of Concern: A Systematic Review.<h4>Background</h4>Methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), methicillin-resistant coagulase-negative <i>Staphylococci</i> (MR-CoNS), and vancomycin-resistant <i>Enterococci</i> (VRE) are increasing worldwide and represent a threat for the limited treatment options in pediatric patients and neonates compared to adults. Recommendations in pediatrics are mainly extrapolated from adults' studies.<h4>Methods</h4>A literature search for the treatment of these pathogens in children (<18 years old) was conducted in Embase, MEDLINE, and Cochrane Library. Studies reporting data on single-patient-level outcomes related to a specific antibiotic treatment for multidrug resistant (MDR) Gram-positive bacterial infection in children were included. Studies reporting data from adults and c2023-01-01T00:00:00Z2023 Jan2025-05-29T19:43:00.486Z2025-05-29T19:43:00.486ZS-EPMC99521893683017410.3390/antibiotics12020261