{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(2)"],"submitter":["Alam MB"],"pubmed_abstract":["Each individual has a unique skin tone based on the types and quantities of melanin pigment, and oxidative stress is a key element in melanogenesis regulation. This research sought to understand the in vitro and in vivo antioxidant and depigmenting properties of betel leaves (<i>Piper betle</i> L.) extract (PBL) and the underlying mechanism. Ethyl acetate fractions of PBL (PBLA) demonstrated excellent phenolic content (342 ± 4.02 mgGAE/g) and strong DPPH, ABTS radicals, and nitric oxide (NO) scavenging activity with an IC<sub>50</sub> value of 41.52 ± 1.02 μg/mL, 45.60 ± 0.56 μg/mL, and 51.42 ± 1.25 μg/mL, respectively. Contrarily, ethanolic extract of PBL (PBLE) showed potent mushroom, mice, and human tyrosinase inhibition activity (IC<sub>50</sub> = 7.72 ± 0.98 μg/mL, 20.59 ± 0.83 μg/mL "],"journal":["Antioxidants (Basel, Switzerland)"],"pagination":["374"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9952209"],"repository":["biostudies-literature"],"pubmed_title":["Antioxidant Potential-Rich Betel Leaves (<i>Piper betle</i> L.) Exert Depigmenting Action by Triggering Autophagy and Downregulating MITF/Tyrosinase In Vitro and In Vivo."],"pmcid":["PMC9952209"],"pubmed_authors":["Park NH","Alam MB","Song BR","Lee SH"],"additional_accession":[]},"is_claimable":false,"name":"Antioxidant Potential-Rich Betel Leaves (<i>Piper betle</i> L.) Exert Depigmenting Action by Triggering Autophagy and Downregulating MITF/Tyrosinase In Vitro and In Vivo.","description":"Each individual has a unique skin tone based on the types and quantities of melanin pigment, and oxidative stress is a key element in melanogenesis regulation. This research sought to understand the in vitro and in vivo antioxidant and depigmenting properties of betel leaves (<i>Piper betle</i> L.) extract (PBL) and the underlying mechanism. Ethyl acetate fractions of PBL (PBLA) demonstrated excellent phenolic content (342 ± 4.02 mgGAE/g) and strong DPPH, ABTS radicals, and nitric oxide (NO) scavenging activity with an IC<sub>50</sub> value of 41.52 ± 1.02 μg/mL, 45.60 ± 0.56 μg/mL, and 51.42 ± 1.25 μg/mL, respectively. Contrarily, ethanolic extract of PBL (PBLE) showed potent mushroom, mice, and human tyrosinase inhibition activity (IC<sub>50</sub> = 7.72 ± 0.98 μg/mL, 20.59 ± 0.83 μg/mL ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-05T13:20:31.534Z","creation":"2025-02-18T23:57:40.579Z"},"accession":"S-EPMC9952209","cross_references":{"pubmed":["36829933"],"doi":["10.3390/antiox12020374"]}}