{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cardozo G"],"funding":["Espacio Interdisciplinario Universidad de la República Uruguay","Programa de Alimentos y Salud Humana (PAyS) IDB","Programa de Desarrollo de Ciencias Básicas","Espacio Interdisciplinario_2020 (to R.R.), Universidad de la República, Uruguay","Comisión Sectorial de Investigación Científica","Programa de Alimentos y Salud Humana (PAyS) Uruguay","Sistema Nacional de Investigadores","Comisión Sectorial de Investigación Científica Universidad de la República Uruguay"],"pagination":["408"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9952270"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(2)"],"pubmed_abstract":["Human peroxiredoxin 3 (<i>Hs</i>Prx3) is a thiol-based peroxidase responsible for the reduction of most hydrogen peroxide and peroxynitrite formed in mitochondria. Mitochondrial disfunction can lead to membrane lipoperoxidation, resulting in the formation of lipid-bound fatty acid hydroperoxides (<sub>L</sub>FA-OOHs) which can be released to become free fatty acid hydroperoxides (<sub>f</sub>FA-OOHs). Herein, we report that <i>Hs</i>Prx3 is oxidized and hyperoxidized by <sub>f</sub>FA-OOHs including those derived from arachidonic acid and eicosapentaenoic acid peroxidation at position 15 with remarkably high rate constants of oxidation (>3.5 × 10<sup>7</sup> M<sup>-1</sup>s<sup>-1</sup>) and hyperoxidation (~2 × 10<sup>7</sup> M<sup>-1</sup>s<sup>-1</sup>). The endoperoxide-hydroperoxide P"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Mitochondrial Peroxiredoxin 3 Is Rapidly Oxidized and Hyperoxidized by Fatty Acid Hydroperoxides."],"pmcid":["PMC9952270"],"funding_grant_id":["CSIC_2018","IDB - R.O.U. (4950/OC-UR)","GID2018_34","4950/OC-UR","CSIC i+d 2020 257","Centros Interdisciplinarios 2020","I+D 2020"],"pubmed_authors":["Cardozo G","Mastrogiovanni M","Trujillo M","Radi R","Viera N","Zeida A","Reyes AM"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial Peroxiredoxin 3 Is Rapidly Oxidized and Hyperoxidized by Fatty Acid Hydroperoxides.","description":"Human peroxiredoxin 3 (<i>Hs</i>Prx3) is a thiol-based peroxidase responsible for the reduction of most hydrogen peroxide and peroxynitrite formed in mitochondria. Mitochondrial disfunction can lead to membrane lipoperoxidation, resulting in the formation of lipid-bound fatty acid hydroperoxides (<sub>L</sub>FA-OOHs) which can be released to become free fatty acid hydroperoxides (<sub>f</sub>FA-OOHs). Herein, we report that <i>Hs</i>Prx3 is oxidized and hyperoxidized by <sub>f</sub>FA-OOHs including those derived from arachidonic acid and eicosapentaenoic acid peroxidation at position 15 with remarkably high rate constants of oxidation (>3.5 × 10<sup>7</sup> M<sup>-1</sup>s<sup>-1</sup>) and hyperoxidation (~2 × 10<sup>7</sup> M<sup>-1</sup>s<sup>-1</sup>). The endoperoxide-hydroperoxide P","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-04-08T12:50:12.432Z","creation":"2024-11-20T00:47:00.241Z"},"accession":"S-EPMC9952270","cross_references":{"pubmed":["36829967"],"doi":["10.3390/antiox12020408"]}}