biostudies-literatureWang Sthe Scientific and Technological Development Planning Foundation of Jilin Provincethe Scientific and Technological Developing Scheme of Jilin Provincethe Young Scientists Fund of the National Natural Science Foundation of Chinathe National Natural Science Foundation of China296https://www.ebi.ac.uk/biostudies/studies/S-EPMC9952469biostudies-literatureUnknown12(2)Ginsenosides, active substances in <i>Panax ginseng</i> C. A. Meyer (ginseng), extend lifespan in multiple species, ameliorate age-associated damage, and limit functional decline in multiple tissues. However, their active components and their molecular mechanisms are largely unknown. Here, ginsenoside Rg1 (Rg1) promoted longevity in <i>Saccharomyces cerevisiae</i>. Treatment with Rg1 decreased aging-mediated surface wrinkling, enhanced stress resistance, decreased reactive oxygen species' production and apoptosis, improved antioxidant enzyme activity, and decreased the aging rate. Proteomic analysis indicated that Rg1 delays <i>S. cerevisiae</i> senescence by regulating metabolic homeostasis. Protein-protein interaction networks based on differential protein expression indicated that CDC19Antioxidants (Basel, Switzerland)Ginsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19- and SDH2-Mediated Cellular Metabolism.PMC9952469U19A2013YDZJ202201ZYTS68320210204188YY82004074Pan DYu SChen JLiu MWang SJiang CLiu SZhao DQiao JZhang PfalseGinsenoside Rg1 Delays Chronological Aging in a Yeast Model via CDC19- and SDH2-Mediated Cellular Metabolism.Ginsenosides, active substances in <i>Panax ginseng</i> C. A. Meyer (ginseng), extend lifespan in multiple species, ameliorate age-associated damage, and limit functional decline in multiple tissues. However, their active components and their molecular mechanisms are largely unknown. Here, ginsenoside Rg1 (Rg1) promoted longevity in <i>Saccharomyces cerevisiae</i>. Treatment with Rg1 decreased aging-mediated surface wrinkling, enhanced stress resistance, decreased reactive oxygen species' production and apoptosis, improved antioxidant enzyme activity, and decreased the aging rate. Proteomic analysis indicated that Rg1 delays <i>S. cerevisiae</i> senescence by regulating metabolic homeostasis. Protein-protein interaction networks based on differential protein expression indicated that CDC192023-01-01T00:00:00Z2023 Jan2025-04-05T13:20:53.278Z2025-02-18T23:58:01.567ZS-EPMC99524693682985510.3390/antiox12020296