biostudies-literatureDrouet CAgence Nationale de la RechercheFederal Ministry of Education and Research220https://www.ebi.ac.uk/biostudies/studies/S-EPMC9952497biostudies-literatureUnknown10(2)Biomimetic nanocrystalline apatites analogous to bone mineral can be prepared using soft chemistry. Due to their high similarity to bone apatite, as opposed to stoichiometric hydroxyapatite for example, they now represent an appealing class of compounds to produce bioactive ceramics for which drug delivery and ion exchange abilities have been described extensively. However, immersion in aqueous media of dried non-carbonated biomimetic apatite crystals may generate an acidification event, which is often disregarded and not been clarified to-date. Yet, this acidification process could limit their further development if it is not understood and overcome if necessary. This may, for example, alter biological test outcomes, during their evaluation as bone repair materials, due to potentially delBioengineering (Basel, Switzerland)Nanocrystalline Apatites: Post-Immersion Acidification and How to Avoid It-Application to Antibacterial Bone Substitutes.PMC9952497PICF call - Biocapabili project (BMBF)PICF call - BioCapabili projectKohl CGWeber FEDrouet CBurger-Kentischer ATrick IMueller MVandecandelaere NMaucher TfalseNanocrystalline Apatites: Post-Immersion Acidification and How to Avoid It-Application to Antibacterial Bone Substitutes.Biomimetic nanocrystalline apatites analogous to bone mineral can be prepared using soft chemistry. Due to their high similarity to bone apatite, as opposed to stoichiometric hydroxyapatite for example, they now represent an appealing class of compounds to produce bioactive ceramics for which drug delivery and ion exchange abilities have been described extensively. However, immersion in aqueous media of dried non-carbonated biomimetic apatite crystals may generate an acidification event, which is often disregarded and not been clarified to-date. Yet, this acidification process could limit their further development if it is not understood and overcome if necessary. This may, for example, alter biological test outcomes, during their evaluation as bone repair materials, due to potentially del2023-01-01T00:00:00Z2023 Feb2025-04-05T13:20:22.374Z2025-02-18T23:58:00.97ZS-EPMC99524973682971410.3390/bioengineering10020220