biostudies-literatureScagnoli Fby Minitero Università e Ricerca and CNRMinistero Università e Ricerca and CNRItalian Association for Cancer ResearchAIRC IG412https://www.ebi.ac.uk/biostudies/studies/S-EPMC9952900biostudies-literatureUnknown11(2)MYC oncoprotein deregulation is a common catastrophic event in human cancer and limiting its activity restrains tumor development and maintenance, as clearly shown via Omomyc, an MYC-interfering 90 amino acid mini-protein. MYC is a multifunctional transcription factor that regulates many aspects of transcription by RNA polymerase II (RNAPII), such as transcription activation, pause release, and elongation. MYC directly associates with Protein Arginine Methyltransferase 5 (PRMT5), a protein that methylates a variety of targets, including RNAPII at the arginine residue R1810 (R1810me2s), crucial for proper transcription termination and splicing of transcripts. Therefore, we asked whether MYC controls termination as well, by affecting R1810me2S. We show that MYC overexpression strongly increaBiomedicinesA New Insight into MYC Action: Control of RNA Polymerase II Methylation and Transcription Termination.PMC995290015927Flagship Epigen ProjectScagnoli FIlli BNasi SPalma AFavia AScuoppo CfalseA New Insight into MYC Action: Control of RNA Polymerase II Methylation and Transcription Termination.MYC oncoprotein deregulation is a common catastrophic event in human cancer and limiting its activity restrains tumor development and maintenance, as clearly shown via Omomyc, an MYC-interfering 90 amino acid mini-protein. MYC is a multifunctional transcription factor that regulates many aspects of transcription by RNA polymerase II (RNAPII), such as transcription activation, pause release, and elongation. MYC directly associates with Protein Arginine Methyltransferase 5 (PRMT5), a protein that methylates a variety of targets, including RNAPII at the arginine residue R1810 (R1810me2s), crucial for proper transcription termination and splicing of transcripts. Therefore, we asked whether MYC controls termination as well, by affecting R1810me2S. We show that MYC overexpression strongly increa2023-01-01T00:00:00Z2023 Jan2026-06-25T03:22:31.323Z2025-05-29T19:43:07.888ZS-EPMC99529003683094810.3390/biomedicines11020412