biostudies-literatureRather TBSher-I-Kashmir Institute of Medical Sciences, Kashmir, IndiaThe study was funded by Sher-I- Kashmir Institute of Medical Sciences, Kashmir, India;540https://www.ebi.ac.uk/biostudies/studies/S-EPMC9953361biostudies-literatureUnknown11(2)<h4>Background</h4>Suppressor of fused (<i>SuFu</i>) is a tumor-suppressor gene that regulates hedgehog signaling. Its involvement in some malignancies is broadly accepted. However, its association with colorectal cancer (CRC) pathogenesis is not clear. Likewise, no study has clearly associated blood-based inflammatory biomarkers with cancer diagnosis/prognosis as yet.<h4>Aim</h4>Our goal was to look at <i>SuFu</i> expression levels in CRC patients and its relationship with other clinicopathological factors. Additionally, we looked into the function of a few blood-based biomarkers in CRC and whether or not a combined strategy at the genetic and clinical levels can be applied in CRC.<h4>Methods</h4>The investigation included 98 histopathologically confirmed CRC samples and adjacent normal tBiomedicinesColorectal Cancer (CRC): Investigating the Expression of the Suppressor of Fused (<i>SuFu</i>) Gene and Its Relationship with Several Inflammatory Blood-Based Biomarkers.PMC9953361SIMS/ACAD 877 OF 2019Rather TBRashid GKhan IYBesina SMudassar SWani RAParveiz IAkhtar KAli MBhat GAHaque ROla MSfalseColorectal Cancer (CRC): Investigating the Expression of the Suppressor of Fused (<i>SuFu</i>) Gene and Its Relationship with Several Inflammatory Blood-Based Biomarkers.<h4>Background</h4>Suppressor of fused (<i>SuFu</i>) is a tumor-suppressor gene that regulates hedgehog signaling. Its involvement in some malignancies is broadly accepted. However, its association with colorectal cancer (CRC) pathogenesis is not clear. Likewise, no study has clearly associated blood-based inflammatory biomarkers with cancer diagnosis/prognosis as yet.<h4>Aim</h4>Our goal was to look at <i>SuFu</i> expression levels in CRC patients and its relationship with other clinicopathological factors. Additionally, we looked into the function of a few blood-based biomarkers in CRC and whether or not a combined strategy at the genetic and clinical levels can be applied in CRC.<h4>Methods</h4>The investigation included 98 histopathologically confirmed CRC samples and adjacent normal t2023-01-01T00:00:00Z2023 Feb2025-04-21T17:24:41.184Z2024-12-04T12:38:31.534ZS-EPMC99533613683107610.3390/biomedicines11020540