{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2(4)"],"submitter":["Keenan T"],"pubmed_abstract":["A highly efficient, cost-effective, and environmentally friendly protocol is reported for the C5-selective alkylation of hydantoins under phase-transfer catalysis. The reactions are scalable and only require a catalytic amount of tetrabutylammonium bromide (TBAB) to achieve high yields under mild reaction conditions. Moreover, the method is applicable to a wide range of electrophiles, including alkyl-, allyl-, propargyl-, and benzyl halides, as well as acrylates and dibromoalkanes, but also to virtually any hydantoin precursor. We also highlight the potential for an enantioselective adaptation using a chiral phase-transfer catalyst."],"journal":["ACS organic & inorganic Au"],"pagination":["312-317"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9954259"],"repository":["biostudies-literature"],"pubmed_title":["Phase-Transfer-Catalyzed Alkylation of Hydantoins."],"pmcid":["PMC9954259"],"pubmed_authors":["Keenan T","Jean A","Arseniyadis S"],"additional_accession":[]},"is_claimable":false,"name":"Phase-Transfer-Catalyzed Alkylation of Hydantoins.","description":"A highly efficient, cost-effective, and environmentally friendly protocol is reported for the C5-selective alkylation of hydantoins under phase-transfer catalysis. The reactions are scalable and only require a catalytic amount of tetrabutylammonium bromide (TBAB) to achieve high yields under mild reaction conditions. Moreover, the method is applicable to a wide range of electrophiles, including alkyl-, allyl-, propargyl-, and benzyl halides, as well as acrylates and dibromoalkanes, but also to virtually any hydantoin precursor. We also highlight the potential for an enantioselective adaptation using a chiral phase-transfer catalyst.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-26T10:20:07.247Z","creation":"2025-04-06T13:17:38.46Z"},"accession":"S-EPMC9954259","cross_references":{"pubmed":["36855589"],"doi":["10.1021/acsorginorgau.1c00058"]}}