biostudies-literatureUnknown9(2)Jayabhavan SSThe nature of functional groups and their relative position and orientation play an important role in tuning the gelation properties of stimuli-responsive supramolecular gels. In this work, we synthesized and characterized mono-/bis-pyridyl-<i>N</i>-oxide compounds of <i>N</i>-(4-pyridyl)nicotinamide (<b>L₁</b>-<b>L₃</b>). The gelation properties of these <i>N</i>-oxide compounds were compared with the reported isomeric counterpart mono-/bis-pyridyl-<i>N</i>-oxide compounds of <i>N</i>-(4-pyridyl)isonicotinamide. Hydrogels obtained with <b>L₁</b> and <b>L₃</b> were thermally and mechanically more stable than the corresponding isomeric counterparts. The surface morphology of the xerogels of di-<i>N</i>-oxides (<b>L₃</b> and <b>diNO</b>)Gels (Basel, Switzerland)89https://www.ebi.ac.uk/biostudies/studies/S-EPMC9956205biostudies-literatureStimuli-Responsive Properties of Supramolecular Gels Based on Pyridyl-<i>N</i>-oxide Amides.PMC9956205Damodaran KKJayabhavan SSKristinsson BGhosh DBreton CfalseStimuli-Responsive Properties of Supramolecular Gels Based on Pyridyl-<i>N</i>-oxide Amides.The nature of functional groups and their relative position and orientation play an important role in tuning the gelation properties of stimuli-responsive supramolecular gels. In this work, we synthesized and characterized mono-/bis-pyridyl-<i>N</i>-oxide compounds of <i>N</i>-(4-pyridyl)nicotinamide (<b>L₁</b>-<b>L₃</b>). The gelation properties of these <i>N</i>-oxide compounds were compared with the reported isomeric counterpart mono-/bis-pyridyl-<i>N</i>-oxide compounds of <i>N</i>-(4-pyridyl)isonicotinamide. Hydrogels obtained with <b>L₁</b> and <b>L₃</b> were thermally and mechanically more stable than the corresponding isomeric counterparts. The surface morphology of the xerogels of di-<i>N</i>-oxides (<b>L₃</b> and <b>diNO</b>)2023-01-01T00:00:00Z2023 Jan2025-04-05T13:21:02.82Z2025-04-05T13:21:02.82ZS-EPMC99562053682625910.3390/gels9020089