biostudies-literatureFierheller CTScholarship Award from The Ministry of Education, Saudi ArabiaFRQS and Quebec Breast Cancer Foundationthe NIHR Cambridge Biomedical Research CentreFonds de recherche du Québec, McGill UniversityNational Institute for Health Research (NIHR)Cancer Research Society and Ovarian Cancer Canada partnershipCanadian Institutes of Health ResearchCIHR277https://www.ebi.ac.uk/biostudies/studies/S-EPMC9956348biostudies-literatureUnknown14(2)<i>FANCI</i> was recently identified as a new candidate ovarian cancer (OC)-predisposing gene from the genetic analysis of carriers of <i>FANCI</i> c.1813C>T; p.L605F in OC families. Here, we aimed to investigate the molecular genetic characteristics of <i>FANCI,</i> as they have not been described in the context of cancer. We first investigated the germline genetic landscape of two sisters with OC from the discovery <i>FANCI</i> c.1813C>T; p.L605F family (F1528) to re-affirm the plausibility of this candidate. As we did not find other conclusive candidates, we then performed a candidate gene approach to identify other candidate variants in genes involved in the FANCI protein interactome in OC families negative for pathogenic variants in <i>BRCA1</i>, <i>BRCA2</i>, <i>BRIP1</i>, <i>RAD51C<GenesMolecular Genetic Characteristics of <i>FANCI</i>, a Proposed New Ovarian Cancer Predisposing Gene.PMC9956348PCC-156736MOP-11507121123PJT-152989PJT-156124BRC-1215-20014Bruce JPBouchard LMes-Masson AMTonin PNFierheller CTPugh TJTischkowitz MAmuzu SEl Haffaf ZBedard KRagoussis JSubramanian DNCampbell IGSerruya CFewings ERevil TFoulkes WDGreenwood CMTProvencher DProkopec SAlenezi WMfalseMolecular Genetic Characteristics of <i>FANCI</i>, a Proposed New Ovarian Cancer Predisposing Gene.<i>FANCI</i> was recently identified as a new candidate ovarian cancer (OC)-predisposing gene from the genetic analysis of carriers of <i>FANCI</i> c.1813C>T; p.L605F in OC families. Here, we aimed to investigate the molecular genetic characteristics of <i>FANCI,</i> as they have not been described in the context of cancer. We first investigated the germline genetic landscape of two sisters with OC from the discovery <i>FANCI</i> c.1813C>T; p.L605F family (F1528) to re-affirm the plausibility of this candidate. As we did not find other conclusive candidates, we then performed a candidate gene approach to identify other candidate variants in genes involved in the FANCI protein interactome in OC families negative for pathogenic variants in <i>BRCA1</i>, <i>BRCA2</i>, <i>BRIP1</i>, <i>RAD51C<2023-01-01T00:00:00Z2023 Jan2026-04-07T13:23:55.039Z2025-04-05T20:45:47.157ZS-EPMC99563483683320310.3390/genes14020277