biostudies-literatureBeauchamp GNational Institute of Allergy and Infectious DiseasesNIAID NIH HHSNIMH NIH HHSe0281728https://www.ebi.ac.uk/biostudies/studies/S-EPMC9956790biostudies-literatureUnknown18(2)<h4>Background</h4>African adolescent girls and young women (AGYW) represent a large proportion of new HIV infections, a priority population for pre-exposure prophylaxis (PrEP), but adherence remains a challenge. A reliable, valid readiness tool would help identify AGYW motivated to take PrEP who need adherence support.<h4>Methods</h4>In the HPTN 082 open-label PrEP study (2016-2019), South African and Zimbabwean women ages 16-25 were administered an HIV prevention readiness measure (HPRM). The 25 items in the HPRM included medication beliefs, connection with care, disclosure of PrEP use, social support, and housing stability using a 5-point Likert scale. Exploratory factor analysis (EFA) using polychoric correlations, scale reliability, and predictive validity were performed on data from PloS oneDevelopment of a tool to assess HIV prevention readiness of adolescent girls and young women in HPTN 082 study.PMC9956790UM1 AI069436UM1AI068619UM1 AI068613P30 MH123248UM1-AI068613UM1 AI068617UM1 AI068619UM1 AI069463UM1-AI068617U01 AI069436Donnell DJMgodi NCelum CDye BJAnderson PLHPTN 082 study teamHosek SChan KCGFlaherty BPBekker LGBeauchamp GDelany-Moretlwe SfalseDevelopment of a tool to assess HIV prevention readiness of adolescent girls and young women in HPTN 082 study.<h4>Background</h4>African adolescent girls and young women (AGYW) represent a large proportion of new HIV infections, a priority population for pre-exposure prophylaxis (PrEP), but adherence remains a challenge. A reliable, valid readiness tool would help identify AGYW motivated to take PrEP who need adherence support.<h4>Methods</h4>In the HPTN 082 open-label PrEP study (2016-2019), South African and Zimbabwean women ages 16-25 were administered an HIV prevention readiness measure (HPRM). The 25 items in the HPRM included medication beliefs, connection with care, disclosure of PrEP use, social support, and housing stability using a 5-point Likert scale. Exploratory factor analysis (EFA) using polychoric correlations, scale reliability, and predictive validity were performed on data from 2023-01-01T00:00:00Z20232026-05-29T05:29:59.044Z2025-02-18T23:44:49.464ZS-EPMC99567903682744010.1371/journal.pone.0281728