biostudies-literatureSyding LACzech Academy of SciencesNGO “Association of Gene Therapy (ASGENT)285https://www.ebi.ac.uk/biostudies/studies/S-EPMC9956889biostudies-literatureUnknown14(2)Stress responses are activated by the hypothalamic-pituitary-adrenal axis (HPA axis), culminating in the release of glucocorticoids. During prolonged periods of secretion of glucocorticoids or inappropriate behavioral responses to a stressor, pathologic conditions may occur. Increased glucocorticoid concentration is linked to generalized anxiety, and there are knowledge gaps regarding its regulation. It is known that the HPA axis is under GABAergic control, but the contribution of the individual subunits of the GABA receptor is largely unknown. In this study, we investigated the relationship between the α5 subunit and corticosterone levels in a new mouse model deficient for <i>Gabra5</i>, which is known to be linked to anxiety disorders in humans and phenologs observed in mice. We observedGenesAblation of <i>Gabra5</i> Influences Corticosterone Levels and Anxiety-like Behavior in Mice.PMC9956889765269Nickl PSyding LATurecek RKralikova MKubik-Zahorodna AProchazka JKopkanova JKasparek PRozman JHruskova BSedlacek RReguera DPNovosadova VfalseAblation of <i>Gabra5</i> Influences Corticosterone Levels and Anxiety-like Behavior in Mice.Stress responses are activated by the hypothalamic-pituitary-adrenal axis (HPA axis), culminating in the release of glucocorticoids. During prolonged periods of secretion of glucocorticoids or inappropriate behavioral responses to a stressor, pathologic conditions may occur. Increased glucocorticoid concentration is linked to generalized anxiety, and there are knowledge gaps regarding its regulation. It is known that the HPA axis is under GABAergic control, but the contribution of the individual subunits of the GABA receptor is largely unknown. In this study, we investigated the relationship between the α5 subunit and corticosterone levels in a new mouse model deficient for <i>Gabra5</i>, which is known to be linked to anxiety disorders in humans and phenologs observed in mice. We observed2023-01-01T00:00:00Z2023 Jan2026-05-16T03:12:03.131Z2025-02-18T23:44:02.876ZS-EPMC99568893683321310.3390/genes14020285