biostudies-literatureChu BNational Natural Science Foundation of Chinae2022GH000705https://www.ebi.ac.uk/biostudies/studies/S-EPMC9958002biostudies-literatureUnknown7(3)The United States of America (USA) was afflicted by extreme heat in the summer of 2021 and some states experienced a record-hot or top-10 hottest summer. Meanwhile, the United States was also one of the countries impacted most by the coronavirus disease 2019 (COVID-19) pandemic. Growing numbers of studies have revealed that meteorological factors such as temperature may influence the number of confirmed COVID-19 cases and deaths. However, the associations between temperature and COVID-19 severity differ in various study areas and periods, especially in periods of high temperatures. Here we choose 119 US counties with large counts of COVID-19 deaths during the summer of 2021 to examine the relationship between COVID-19 deaths and temperature by applying a two-stage epidemiological analyticaGeoHealthEffects of High Temperature on COVID-19 Deaths in U.S. Counties.PMC995800292143301821037907197409292043301Chu BLiu QWang HChen RfalseEffects of High Temperature on COVID-19 Deaths in U.S. Counties.The United States of America (USA) was afflicted by extreme heat in the summer of 2021 and some states experienced a record-hot or top-10 hottest summer. Meanwhile, the United States was also one of the countries impacted most by the coronavirus disease 2019 (COVID-19) pandemic. Growing numbers of studies have revealed that meteorological factors such as temperature may influence the number of confirmed COVID-19 cases and deaths. However, the associations between temperature and COVID-19 severity differ in various study areas and periods, especially in periods of high temperatures. Here we choose 119 US counties with large counts of COVID-19 deaths during the summer of 2021 to examine the relationship between COVID-19 deaths and temperature by applying a two-stage epidemiological analytica2023-01-01T00:00:00Z2023 Mar2026-03-27T15:44:53.816Z2025-04-04T08:52:54.834ZS-EPMC99580023685218110.1029/2022GH000705