{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lyu M"],"funding":["National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["82"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9958017"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Alternative splicing (AS) is an important approach for pathogens and hosts to remodel transcriptome. However, tuberculosis (TB)-related AS has not been sufficiently explored. Here we presented the first landscape of TB-related AS by long-read sequencing, and screened four AS events (S100A8-intron1-retention intron, RPS20-exon1-alternaitve promoter, KIF13B-exon4-skipping exon (SE) and UBE2B-exon7-SE) as potential biomarkers in an in-house cohort-1. The validations in an in-house cohort-2 (2274 samples) and public datasets (1557 samples) indicated that the latter three AS events are potential promising biomarkers for TB diagnosis, but not for TB progression and prognosis. The excellent performance of classifiers further underscored the diagnostic value of these three biomarkers. Subgroup ana"],"journal":["Signal transduction and targeted therapy"],"pubmed_title":["From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism."],"pmcid":["PMC9958017"],"funding_grant_id":["U20A20394","82272416"],"pubmed_authors":["Lai H","Gong S","Zengwanggema","Wang C","Chen L","Zhou Y","Yao X","Hai Y","Ying B","Lyu M","Chong W","Wang Q","Zeng J","Niu L","Chen Y","Wang Y","Xu W","Zhou J"],"additional_accession":[]},"is_claimable":false,"name":"From tuberculosis bedside to bench: UBE2B splicing as a potential biomarker and its regulatory mechanism.","description":"Alternative splicing (AS) is an important approach for pathogens and hosts to remodel transcriptome. However, tuberculosis (TB)-related AS has not been sufficiently explored. Here we presented the first landscape of TB-related AS by long-read sequencing, and screened four AS events (S100A8-intron1-retention intron, RPS20-exon1-alternaitve promoter, KIF13B-exon4-skipping exon (SE) and UBE2B-exon7-SE) as potential biomarkers in an in-house cohort-1. The validations in an in-house cohort-2 (2274 samples) and public datasets (1557 samples) indicated that the latter three AS events are potential promising biomarkers for TB diagnosis, but not for TB progression and prognosis. The excellent performance of classifiers further underscored the diagnostic value of these three biomarkers. Subgroup ana","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-28T08:15:21.266Z","creation":"2024-11-07T06:05:20.5Z"},"accession":"S-EPMC9958017","cross_references":{"pubmed":["36828823"],"doi":["10.1038/s41392-023-01346-2"]}}