{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jia J"],"funding":["National Natural Science Foundation of China","Natural Science Foundation of Jiangsu Province"],"pagination":["156"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9958101"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(2)"],"pubmed_abstract":["Ischemic stroke leads to white matter damage and neurological deficits. However, the characteristics of white matter injury and repair after stroke are unclear. Additionally, the precise molecular communications between microglia and white matter repair during the stroke rehabilitation phase remain elusive. In this current study, MRI DTI scan and immunofluorescence staining were performed to trace white matter and microglia in the mouse transient middle cerebral artery occlusion (tMCAO) stroke model. We found that the most serious white matter damage was on Day 7 after the ischemic stroke, then it recovered gradually from Day 7 to Day 30. Parallel to white matter recovery, we observed that microglia centered around the damaged myelin sheath and swallowed myelin debris in the ischemic areas"],"journal":["Cell death & disease"],"pubmed_title":["CD11c<sup>+</sup> microglia promote white matter repair after ischemic stroke."],"pmcid":["PMC9958101"],"funding_grant_id":["BK20191116","81971112, 82130036, 81920208017"],"pubmed_authors":["Ye L","Shu S","Chen J","Zheng L","Bao X","Xu S","Xia S","Liu R","Zhang M","Jia J","Xu Y"],"additional_accession":[]},"is_claimable":false,"name":"CD11c<sup>+</sup> microglia promote white matter repair after ischemic stroke.","description":"Ischemic stroke leads to white matter damage and neurological deficits. However, the characteristics of white matter injury and repair after stroke are unclear. Additionally, the precise molecular communications between microglia and white matter repair during the stroke rehabilitation phase remain elusive. In this current study, MRI DTI scan and immunofluorescence staining were performed to trace white matter and microglia in the mouse transient middle cerebral artery occlusion (tMCAO) stroke model. We found that the most serious white matter damage was on Day 7 after the ischemic stroke, then it recovered gradually from Day 7 to Day 30. Parallel to white matter recovery, we observed that microglia centered around the damaged myelin sheath and swallowed myelin debris in the ischemic areas","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-28T17:47:53.953Z","creation":"2025-04-04T11:27:02.962Z"},"accession":"S-EPMC9958101","cross_references":{"pubmed":["36828819"],"doi":["10.1038/s41419-023-05689-0"]}}