{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu Y"],"funding":["Natural Science Foundation of China"],"pagination":["827-840"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9958166"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["43(2)"],"pubmed_abstract":["Abnormal amino acid metabolism in neural cells is involved in the occurrence and development of major depressive disorder. Taurine is an important amino acid required for brain development. Here, microdialysis combined with metabonomic analysis revealed that the level of taurine in the extracellular fluid of the cerebral medial prefrontal cortex (mPFC) was significantly reduced in mice with chronic social defeat stress (CSDS)-induced depression. Therefore, taurine supplementation may be usable an intervention for depression. We found that taurine supplementation effectively rescued immobility time during a tail suspension assay and improved social avoidance behaviors in CSDS mice. Moreover, taurine treatment protected CSDS mice from impairments in dendritic complexity, spine density, and t"],"journal":["Cellular and molecular neurobiology"],"pubmed_title":["Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss."],"pmcid":["PMC9958166"],"funding_grant_id":["81730035","82071538","92057111"],"pubmed_authors":["Zhuo L","Li X","Li Y","Zhu Y","Wang R","Fan Z","Zhang H","Wu S","Han J","Zhang L","Luo D","Cai G"],"additional_accession":[]},"is_claimable":false,"name":"Taurine Alleviates Chronic Social Defeat Stress-Induced Depression by Protecting Cortical Neurons from Dendritic Spine Loss.","description":"Abnormal amino acid metabolism in neural cells is involved in the occurrence and development of major depressive disorder. Taurine is an important amino acid required for brain development. Here, microdialysis combined with metabonomic analysis revealed that the level of taurine in the extracellular fluid of the cerebral medial prefrontal cortex (mPFC) was significantly reduced in mice with chronic social defeat stress (CSDS)-induced depression. Therefore, taurine supplementation may be usable an intervention for depression. We found that taurine supplementation effectively rescued immobility time during a tail suspension assay and improved social avoidance behaviors in CSDS mice. Moreover, taurine treatment protected CSDS mice from impairments in dendritic complexity, spine density, and t","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-03-31T11:52:58.273Z","creation":"2025-04-06T09:05:04.665Z"},"accession":"S-EPMC9958166","cross_references":{"pubmed":["35435537"],"doi":["10.1007/s10571-022-01218-3"]}}