biostudies-literatureCafournet CFrench Muscular Dystrophy AssociationAgence Nationale de la Recherche445https://www.ebi.ac.uk/biostudies/studies/S-EPMC9958991biostudies-literatureUnknown13(2)Transcription of mitochondrial DNA generates long polycistronic precursors whose nucleolytic cleavage yields the individual mtDNA-encoded transcripts. In most cases, this cleavage occurs at the 5'- and 3'-ends of tRNA sequences by the concerted action of RNAseP and RNaseZ/ELAC2 endonucleases, respectively. Variants in the <i>ELAC2</i> gene have been predominantly linked to severe to mild cardiomyopathy that, in its milder forms, is accompanied by variably severe neurological presentations. Here, we report five patients from three unrelated families. Four of the patients presented mild to moderate cardiomyopathy and one died at 1 year of age, one patient had no evidence of cardiomyopathy. The patients had variable neurological presentations that included intellectual disability, ataxia, refLife (Basel, Switzerland)Novel ELAC2 Mutations in Individuals Presenting with Variably Severe Neurological Disease in the Presence or Absence of Cardiomyopathy.PMC995899119876GENOMITANR-15-RAR3-0012-072252919876, 22529Ruzzenente BMetodiev MDCafournet CZanin SRotig AGuimier AMunnich ABonnefont JPHully Mde Lonlay PBarcia GAssouline ZSteffann JfalseNovel ELAC2 Mutations in Individuals Presenting with Variably Severe Neurological Disease in the Presence or Absence of Cardiomyopathy.Transcription of mitochondrial DNA generates long polycistronic precursors whose nucleolytic cleavage yields the individual mtDNA-encoded transcripts. In most cases, this cleavage occurs at the 5'- and 3'-ends of tRNA sequences by the concerted action of RNAseP and RNaseZ/ELAC2 endonucleases, respectively. Variants in the <i>ELAC2</i> gene have been predominantly linked to severe to mild cardiomyopathy that, in its milder forms, is accompanied by variably severe neurological presentations. Here, we report five patients from three unrelated families. Four of the patients presented mild to moderate cardiomyopathy and one died at 1 year of age, one patient had no evidence of cardiomyopathy. The patients had variable neurological presentations that included intellectual disability, ataxia, ref2023-01-01T00:00:00Z2023 Feb2025-04-21T17:23:45.207Z2024-12-04T12:38:16.092ZS-EPMC99589913683680210.3390/life13020445