{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kozlik-Siwiec P"],"funding":["National Science Centre of the Polish Ministry of Science"],"pagination":["3789"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9959255"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(4)"],"pubmed_abstract":["Asthma heterogeneity complicates the search for targeted treatment against airway inflammation and remodeling. We sought to investigate relations between eosinophilic inflammation, a phenotypic feature frequent in severe asthma, bronchial epithelial transcriptome, and functional and structural measures of airway remodeling. We compared epithelial gene expression, spirometry, airway cross-sectional geometry (computed tomography), reticular basement membrane thickness (histology), and blood and bronchoalveolar lavage (BAL) cytokines of <i>n</i> = 40 moderate to severe eosinophilic (EA) and non-eosinophilic asthma (NEA) patients distinguished by BAL eosinophilia. EA patients showed a similar extent of airway remodeling as NEA but had an increased expression of genes involved in the immune res"],"journal":["International journal of molecular sciences"],"pubmed_title":["Co-Expression Analysis of Airway Epithelial Transcriptome in Asthma Patients with Eosinophilic vs. Non-Eosinophilic Airway Infiltration."],"pmcid":["PMC9959255"],"funding_grant_id":["DEC-2013/09/B/NZ5/00758"],"pubmed_authors":["Okon K","Zuk-Kuwik J","Jakiela B","Dziedzina S","Siwiec-Kozlik A","Soja J","Zareba L","Bazan JG","Myszka A","Bazan-Socha S","Kepski M","Zawlik I","Zarychta J","Kozlik-Siwiec P","Buregwa-Czuma S"],"additional_accession":[]},"is_claimable":false,"name":"Co-Expression Analysis of Airway Epithelial Transcriptome in Asthma Patients with Eosinophilic vs. Non-Eosinophilic Airway Infiltration.","description":"Asthma heterogeneity complicates the search for targeted treatment against airway inflammation and remodeling. We sought to investigate relations between eosinophilic inflammation, a phenotypic feature frequent in severe asthma, bronchial epithelial transcriptome, and functional and structural measures of airway remodeling. We compared epithelial gene expression, spirometry, airway cross-sectional geometry (computed tomography), reticular basement membrane thickness (histology), and blood and bronchoalveolar lavage (BAL) cytokines of <i>n</i> = 40 moderate to severe eosinophilic (EA) and non-eosinophilic asthma (NEA) patients distinguished by BAL eosinophilia. EA patients showed a similar extent of airway remodeling as NEA but had an increased expression of genes involved in the immune res","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-20T01:36:17.221Z","creation":"2025-02-18T23:57:59.124Z"},"accession":"S-EPMC9959255","cross_references":{"pubmed":["36835202"],"doi":["10.3390/ijms24043789"]}}