biostudies-literatureKozlik-Siwiec PNational Science Centre of the Polish Ministry of Science3789https://www.ebi.ac.uk/biostudies/studies/S-EPMC9959255biostudies-literatureUnknown24(4)Asthma heterogeneity complicates the search for targeted treatment against airway inflammation and remodeling. We sought to investigate relations between eosinophilic inflammation, a phenotypic feature frequent in severe asthma, bronchial epithelial transcriptome, and functional and structural measures of airway remodeling. We compared epithelial gene expression, spirometry, airway cross-sectional geometry (computed tomography), reticular basement membrane thickness (histology), and blood and bronchoalveolar lavage (BAL) cytokines of <i>n</i> = 40 moderate to severe eosinophilic (EA) and non-eosinophilic asthma (NEA) patients distinguished by BAL eosinophilia. EA patients showed a similar extent of airway remodeling as NEA but had an increased expression of genes involved in the immune resInternational journal of molecular sciencesCo-Expression Analysis of Airway Epithelial Transcriptome in Asthma Patients with Eosinophilic vs. Non-Eosinophilic Airway Infiltration.PMC9959255DEC-2013/09/B/NZ5/00758Okon KZuk-Kuwik JJakiela BDziedzina SSiwiec-Kozlik ASoja JZareba LBazan JGMyszka ABazan-Socha SKepski MZawlik IZarychta JKozlik-Siwiec PBuregwa-Czuma SfalseCo-Expression Analysis of Airway Epithelial Transcriptome in Asthma Patients with Eosinophilic vs. Non-Eosinophilic Airway Infiltration.Asthma heterogeneity complicates the search for targeted treatment against airway inflammation and remodeling. We sought to investigate relations between eosinophilic inflammation, a phenotypic feature frequent in severe asthma, bronchial epithelial transcriptome, and functional and structural measures of airway remodeling. We compared epithelial gene expression, spirometry, airway cross-sectional geometry (computed tomography), reticular basement membrane thickness (histology), and blood and bronchoalveolar lavage (BAL) cytokines of <i>n</i> = 40 moderate to severe eosinophilic (EA) and non-eosinophilic asthma (NEA) patients distinguished by BAL eosinophilia. EA patients showed a similar extent of airway remodeling as NEA but had an increased expression of genes involved in the immune res2023-01-01T00:00:00Z2023 Feb2025-04-20T01:36:17.221Z2025-02-18T23:57:59.124ZS-EPMC99592553683520210.3390/ijms24043789