{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu Q"],"funding":["Shuangbai Plan from Yantai Municipal City","Taishan Scholar Program from Shandong Province","National Natural Science Foundation of China"],"pagination":["137"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9959855"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(2)"],"pubmed_abstract":["Benthic invertebrates produce secondary metabolites that serve as defenses against consumers and promote their fitness. To explore the chemical defense in marine benthic echinoderms, the chemical constituents of <i>Ophiopholis mirabilis</i> were investigated. A steroidal monoglycoside, asterosaponin P1, was isolated from <i>O. mirabilis</i> for the first-time using column chromatography. The chemical structure was characterized by spectroscopic and spectrometric methods. The embryotoxicity and teratogenicity of the isolated compound were assessed using the zebrafish embryo assay, a powerful vertebrate animal model system to study mechanisms of toxicity. When applied at high concentrations, asterosaponin P1 causes a significant increase in embryo mortality. A moderate LC<sub>50</sub> of ast"],"journal":["Toxics"],"pubmed_title":["Embryotoxicity and Teratogenicity of Steroidal Saponin Isolated from <i>Ophiopholis mirabilis</i>."],"pmcid":["PMC9959855"],"funding_grant_id":["tsqn20190403","2018020","32270533"],"pubmed_authors":["Yang X","Li X","Liu Y","Li Y","Ma B","Lin A","Yan Z","Xu Q","Chen L","Han S","Li K","Zhang R"],"additional_accession":[]},"is_claimable":false,"name":"Embryotoxicity and Teratogenicity of Steroidal Saponin Isolated from <i>Ophiopholis mirabilis</i>.","description":"Benthic invertebrates produce secondary metabolites that serve as defenses against consumers and promote their fitness. To explore the chemical defense in marine benthic echinoderms, the chemical constituents of <i>Ophiopholis mirabilis</i> were investigated. A steroidal monoglycoside, asterosaponin P1, was isolated from <i>O. mirabilis</i> for the first-time using column chromatography. The chemical structure was characterized by spectroscopic and spectrometric methods. The embryotoxicity and teratogenicity of the isolated compound were assessed using the zebrafish embryo assay, a powerful vertebrate animal model system to study mechanisms of toxicity. When applied at high concentrations, asterosaponin P1 causes a significant increase in embryo mortality. A moderate LC<sub>50</sub> of ast","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-22T02:28:12.93Z","creation":"2025-04-05T20:20:52.021Z"},"accession":"S-EPMC9959855","cross_references":{"pubmed":["36851012"],"doi":["10.3390/toxics11020137"]}}