{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["28(4)"],"submitter":["Li X"],"pubmed_abstract":["The PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRp) has been identified as a promising target for the treatment of influenza. To expand the chemical space of the known influenza polymerase PB2 inhibitor-pimodivir (formerly VX-787) and improve its pharmacokinetic profile, two pimodivir analogs containing 2,3-dihydro-imidazopyridine fragment (comp. <b>I</b> and comp. <b>II</b>) were designed, synthesized, and evaluated for anti-influenza virus activity. In the cytopathic effect (CPE) inhibition assay, comp. <b>I</b> and comp. <b>II</b> showed IC<sub>50</sub> values of 0.07 and 0.09 μM for A/Puerto Rico/8/34 (H1N1) and 0.04 and 0.07 μM for A/Hong Kong/8/68 (H3N2), respectively. Protein-binding affinity assay results showed a concentration-dependent association and dissociatio"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["1849"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9960307"],"repository":["biostudies-literature"],"pubmed_title":["Design, Synthesis, Biological Evaluation, and Molecular Dynamics Simulation of Influenza Polymerase PB2 Inhibitors."],"pmcid":["PMC9960307"],"pubmed_authors":["Li W","Li X","Li S","Che J","Cao R","Xu Y","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Design, Synthesis, Biological Evaluation, and Molecular Dynamics Simulation of Influenza Polymerase PB2 Inhibitors.","description":"The PB2 subunit of the influenza RNA-dependent RNA polymerase (RdRp) has been identified as a promising target for the treatment of influenza. To expand the chemical space of the known influenza polymerase PB2 inhibitor-pimodivir (formerly VX-787) and improve its pharmacokinetic profile, two pimodivir analogs containing 2,3-dihydro-imidazopyridine fragment (comp. <b>I</b> and comp. <b>II</b>) were designed, synthesized, and evaluated for anti-influenza virus activity. In the cytopathic effect (CPE) inhibition assay, comp. <b>I</b> and comp. <b>II</b> showed IC<sub>50</sub> values of 0.07 and 0.09 μM for A/Puerto Rico/8/34 (H1N1) and 0.04 and 0.07 μM for A/Hong Kong/8/68 (H3N2), respectively. Protein-binding affinity assay results showed a concentration-dependent association and dissociatio","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2026-05-13T14:28:57.724Z","creation":"2025-02-19T03:26:40.054Z"},"accession":"S-EPMC9960307","cross_references":{"pubmed":["36838837"],"doi":["10.3390/molecules28041849"]}}