{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zheng J"],"funding":["Youth and Middle-aged Scientific and Technological Innovation Leading Talents Program of the Corps","Technology Innovation Seed Fund","Joint Fund for Translational Medicine and Interdisciplinary Research of Zhongnan Hospital of Wuhan University","National Natural Science Foundation of China"],"pagination":["153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9960415"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(1)"],"pubmed_abstract":["<h4>Background</h4>The interaction between the tumor-microenvironment (TME) and the cancer cells has emerged as a key player in colorectal cancer (CRC) metastasis. A small proportion of CRC cells which undergo epithelial-mesenchymal transition (EMT) facilitate the reshaping of the TME by regulating various cellular ingredients.<h4>Methods</h4>Immunohistochemical analysis, RNA immunoprecipitation (RIP), RNA Antisense Purification (RAP), dual luciferase assays were conducted to investigate the biological function and regulation of LINC00543 in CRC. A series in vitro and in vivo experiments were used to clarify the role of LINC00543 in CRC metastasis.<h4>Results</h4>Here we found that the long non-coding RNA LINC00543, was overexpressed in colorectal cancer tissues, which correlated with adva"],"journal":["Journal of translational medicine"],"pubmed_title":["LINC00543 promotes colorectal cancer metastasis by driving EMT and inducing the M2 polarization of tumor associated macrophages."],"pmcid":["PMC9960415"],"funding_grant_id":["ZNJC201913","82173330","WHQG202003","znpy2019076","81572874"],"pubmed_authors":["Zheng J","Huang S","Zhong B","Wang S","Zhang X","Xu Q","Xiong B","Fang C","Lin Z","Dou R","Song J","Di Z"],"additional_accession":[]},"is_claimable":false,"name":"LINC00543 promotes colorectal cancer metastasis by driving EMT and inducing the M2 polarization of tumor associated macrophages.","description":"<h4>Background</h4>The interaction between the tumor-microenvironment (TME) and the cancer cells has emerged as a key player in colorectal cancer (CRC) metastasis. A small proportion of CRC cells which undergo epithelial-mesenchymal transition (EMT) facilitate the reshaping of the TME by regulating various cellular ingredients.<h4>Methods</h4>Immunohistochemical analysis, RNA immunoprecipitation (RIP), RNA Antisense Purification (RAP), dual luciferase assays were conducted to investigate the biological function and regulation of LINC00543 in CRC. A series in vitro and in vivo experiments were used to clarify the role of LINC00543 in CRC metastasis.<h4>Results</h4>Here we found that the long non-coding RNA LINC00543, was overexpressed in colorectal cancer tissues, which correlated with adva","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-05-18T12:54:55.592Z","creation":"2025-04-06T02:27:05.058Z"},"accession":"S-EPMC9960415","cross_references":{"pubmed":["36841801"],"doi":["10.1186/s12967-023-04009-6"]}}